Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review
MicroRNAs (miRNAs) are small noncoding RNAs approximately 22 nucleotides in length. Their main function is to regulate gene expression at the posttranscriptional level by inhibiting the translation of messenger RNAs (mRNAs). miRNAs originate in the cell nucleus from specific genes, where they can pe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/12/1190 |
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| author | Karla G. Hernández-Gómez Azalia Avila-Nava Luis E. González-Salazar Lilia G. Noriega Aurora E. Serralde-Zúñiga Rocio Guizar-Heredia Isabel Medina-Vera Ana Ligia Gutiérrez-Solis Nimbe Torres Armando R. Tovar Martha Guevara-Cruz |
| author_facet | Karla G. Hernández-Gómez Azalia Avila-Nava Luis E. González-Salazar Lilia G. Noriega Aurora E. Serralde-Zúñiga Rocio Guizar-Heredia Isabel Medina-Vera Ana Ligia Gutiérrez-Solis Nimbe Torres Armando R. Tovar Martha Guevara-Cruz |
| author_sort | Karla G. Hernández-Gómez |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small noncoding RNAs approximately 22 nucleotides in length. Their main function is to regulate gene expression at the posttranscriptional level by inhibiting the translation of messenger RNAs (mRNAs). miRNAs originate in the cell nucleus from specific genes, where they can perform their function. However, they can also be found in serum, plasma, or other body fluids travelling within vesicles called exosomes and/or bound to proteins or other particles such as lipoproteins. miRNAs can form complexes outside the cell where they are synthesized, mediating paracrine and endocrine communication between different tissues. In this way, they can modulate the gene expression and function of distal cells. It is known that the expression of miRNAs can be affected by multiple factors, such as the nutritional or pathological state of the individual, or even in conditions such as obesity, insulin resistance, or after any dietary intervention. In this review, we will analyse miRNAs whose expression and circulation are affected in conditions of obesity and insulin resistance, as well as the changes generated after a dietary intervention, with the purpose of identifying new possible biomarkers of early response to nutritional treatment in these conditions. |
| first_indexed | 2024-03-08T20:33:06Z |
| format | Article |
| id | doaj.art-c09307309cd943c293a104a838c30487 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-08T20:33:06Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-c09307309cd943c293a104a838c304872023-12-22T14:24:28ZengMDPI AGMetabolites2218-19892023-12-011312119010.3390/metabo13121190Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative ReviewKarla G. Hernández-Gómez0Azalia Avila-Nava1Luis E. González-Salazar2Lilia G. Noriega3Aurora E. Serralde-Zúñiga4Rocio Guizar-Heredia5Isabel Medina-Vera6Ana Ligia Gutiérrez-Solis7Nimbe Torres8Armando R. Tovar9Martha Guevara-Cruz10Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Mérida 97130, MexicoServicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoServicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Mexico City 04530, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Mérida 97130, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoMicroRNAs (miRNAs) are small noncoding RNAs approximately 22 nucleotides in length. Their main function is to regulate gene expression at the posttranscriptional level by inhibiting the translation of messenger RNAs (mRNAs). miRNAs originate in the cell nucleus from specific genes, where they can perform their function. However, they can also be found in serum, plasma, or other body fluids travelling within vesicles called exosomes and/or bound to proteins or other particles such as lipoproteins. miRNAs can form complexes outside the cell where they are synthesized, mediating paracrine and endocrine communication between different tissues. In this way, they can modulate the gene expression and function of distal cells. It is known that the expression of miRNAs can be affected by multiple factors, such as the nutritional or pathological state of the individual, or even in conditions such as obesity, insulin resistance, or after any dietary intervention. In this review, we will analyse miRNAs whose expression and circulation are affected in conditions of obesity and insulin resistance, as well as the changes generated after a dietary intervention, with the purpose of identifying new possible biomarkers of early response to nutritional treatment in these conditions.https://www.mdpi.com/2218-1989/13/12/1190miRNAexosomesdietobesityinsulin resistance |
| spellingShingle | Karla G. Hernández-Gómez Azalia Avila-Nava Luis E. González-Salazar Lilia G. Noriega Aurora E. Serralde-Zúñiga Rocio Guizar-Heredia Isabel Medina-Vera Ana Ligia Gutiérrez-Solis Nimbe Torres Armando R. Tovar Martha Guevara-Cruz Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review Metabolites miRNA exosomes diet obesity insulin resistance |
| title | Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review |
| title_full | Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review |
| title_fullStr | Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review |
| title_full_unstemmed | Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review |
| title_short | Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review |
| title_sort | modulation of micrornas and exosomal micrornas after dietary interventions for obesity and insulin resistance a narrative review |
| topic | miRNA exosomes diet obesity insulin resistance |
| url | https://www.mdpi.com/2218-1989/13/12/1190 |
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