Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1

Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1

Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The present study investigated the mechanism of BBR on AMPK activation at low doses, which was different from that of metformin.Methods: Lysosomes were isolated, and AMPK activity a...

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Bibliographic Details
Main Authors: Gang Ren, Yu-Wei Ding, Lu-Lu Wang, Jian-Dong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
AMPK
berberine
metformin
AXIN1
UHRF1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1148611/full

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