Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model
Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse effects of OA and relieve associated pain. Globally, knee osteoarthritis (KOA) is the most common type of a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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South Valley University
2022-09-01
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| Series: | SVU-International Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://svu.journals.ekb.eg/article_262407.html |
| _version_ | 1798019375822798848 |
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| author | Asmaa Z. Shabaan Nashwa A.M. Mostafa Reham I. El-Mahdy Ahmed Y. Nassar Mohammed Salah Alsayed Abdelhamid Mohamed AbdulRahman A. Saied Asmaa A. Metwally Mohammed Youssef Ahmed Abdeen Harishkumar Madhyastha Obeid Shanab |
| author_facet | Asmaa Z. Shabaan Nashwa A.M. Mostafa Reham I. El-Mahdy Ahmed Y. Nassar Mohammed Salah Alsayed Abdelhamid Mohamed AbdulRahman A. Saied Asmaa A. Metwally Mohammed Youssef Ahmed Abdeen Harishkumar Madhyastha Obeid Shanab |
| author_sort | Asmaa Z. Shabaan |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and
synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse
effects of OA and relieve associated pain. Globally, knee osteoarthritis (KOA) is the most
common type of arthritis. The present study aimed to evaluate the anti-inflammatory effect
copper albumen complex (cu-albumin complex) for the treatment of mono-iodoacetate (MIA)-
induced KOA in Albino rats. A total of 50 adult male albino rats were involved and divided as
follows; 10 rats were kept normal as negative control; 20 arthritic rats were kept untreated
(positive control), and 20 arthritic rats were treated with cu-albumin complex orally for a month.
Treated and untreated arthritic rats were divided equally (10 rats each) into mild and severe
groups according to the severity of signs. The intra-articular injection of MIA in the right knee
joint was used for induction of osteoarthritis. Using Mankin grading score, the results
demonstrated that the treated groups had a better histological appearance than the control
positive group. Additionally, except for a few shrunken chondrocytes, the mildly treated group
showed less degenerative alterations and appeared virtually normal. While the severe treated
group showed increased cellularity with decreased degenerated chondrocytes. It concluded that
balanced copper consumption has a positive impact on the prevention and treatment of KOA |
| first_indexed | 2024-04-11T16:39:42Z |
| format | Article |
| id | doaj.art-c0949eea0be84ed9b9695741bec3b02c |
| institution | Directory Open Access Journal |
| issn | 2535-1826 2535-1877 |
| language | English |
| last_indexed | 2024-04-11T16:39:42Z |
| publishDate | 2022-09-01 |
| publisher | South Valley University |
| record_format | Article |
| series | SVU-International Journal of Veterinary Sciences |
| spelling | doaj.art-c0949eea0be84ed9b9695741bec3b02c2022-12-22T04:13:43ZengSouth Valley UniversitySVU-International Journal of Veterinary Sciences2535-18262535-18772022-09-015311212510.21608/SVU.2022.136512.1196Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat ModelAsmaa Z. Shabaan0Nashwa A.M. Mostafa1Reham I. El-Mahdy2Ahmed Y. Nassar3Mohammed Salah4Alsayed Abdelhamid Mohamed5AbdulRahman A. Saied6Asmaa A. Metwally7Mohammed Youssef8Ahmed Abdeen9Harishkumar Madhyastha10Obeid Shanab111Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523Department of histology and cell biology, Faculty of Medicine, Assiut University,Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University,Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University,1Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523Department of Anatomy, Faculty of Veterinary Medicine, South Valley University, Qena 83523National Food Safety Authority (NFSA), Aswan Branch, Aswan 81511Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528Center of Excellence for Screening of Environmental Contaminants (CESEC), Faculty of Veterinary Medicine, Benha UniversityDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, EgypDepartment of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523,Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse effects of OA and relieve associated pain. Globally, knee osteoarthritis (KOA) is the most common type of arthritis. The present study aimed to evaluate the anti-inflammatory effect copper albumen complex (cu-albumin complex) for the treatment of mono-iodoacetate (MIA)- induced KOA in Albino rats. A total of 50 adult male albino rats were involved and divided as follows; 10 rats were kept normal as negative control; 20 arthritic rats were kept untreated (positive control), and 20 arthritic rats were treated with cu-albumin complex orally for a month. Treated and untreated arthritic rats were divided equally (10 rats each) into mild and severe groups according to the severity of signs. The intra-articular injection of MIA in the right knee joint was used for induction of osteoarthritis. Using Mankin grading score, the results demonstrated that the treated groups had a better histological appearance than the control positive group. Additionally, except for a few shrunken chondrocytes, the mildly treated group showed less degenerative alterations and appeared virtually normal. While the severe treated group showed increased cellularity with decreased degenerated chondrocytes. It concluded that balanced copper consumption has a positive impact on the prevention and treatment of KOAhttps://svu.journals.ekb.eg/article_262407.htmlaggrcancopperkneemiaosteoarthritisproteoglycan |
| spellingShingle | Asmaa Z. Shabaan Nashwa A.M. Mostafa Reham I. El-Mahdy Ahmed Y. Nassar Mohammed Salah Alsayed Abdelhamid Mohamed AbdulRahman A. Saied Asmaa A. Metwally Mohammed Youssef Ahmed Abdeen Harishkumar Madhyastha Obeid Shanab Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model SVU-International Journal of Veterinary Sciences aggrcan copper knee mia osteoarthritis proteoglycan |
| title | Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model |
| title_full | Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model |
| title_fullStr | Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model |
| title_full_unstemmed | Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model |
| title_short | Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model |
| title_sort | ameliorative effect of copper albumin complex on proteoglycan in mono iodoacetat induced osteoarthritis rat model |
| topic | aggrcan copper knee mia osteoarthritis proteoglycan |
| url | https://svu.journals.ekb.eg/article_262407.html |
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