Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants
The early loss of dental implants can be avoided with systemic antibiotics, however there are potentially significant side effects. Consequently, the use of local drug administration techniques is necessary to make dental implant therapy more practical. In this study, Y-branched nanotubes were prepa...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/13/12/1695 |
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| author | Angela Gabriela Păun Valeria Petrina Nicoleta Badea Camelia Ungureanu Simona Popescu Cristina Dumitriu |
| author_facet | Angela Gabriela Păun Valeria Petrina Nicoleta Badea Camelia Ungureanu Simona Popescu Cristina Dumitriu |
| author_sort | Angela Gabriela Păun |
| collection | DOAJ |
| description | The early loss of dental implants can be avoided with systemic antibiotics, however there are potentially significant side effects. Consequently, the use of local drug administration techniques is necessary to make dental implant therapy more practical. In this study, Y-branched nanotubes were prepared by non-expensive and simple anodization in two steps. Tests were performed to highlight their potential for local antibiotic administration. Y-branched nanotubes were able to incorporate a dose of Tetracycline and ensure its electrochemical stability. The presence of tetracycline significantly enhanced antibacterial efficacy, resulting in an increase of up to 55% for <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> and 50% for <i>Staphylococcus aureus</i>. The comparable antibacterial effects of the nanostructured surfaces highlight the potential of tetracycline in promoting antimicrobial action. Moreover, the addition of tetracycline does not influence the structural, morphological and stability properties of the nanostructured deposited TiO<sub>2</sub> films. |
| first_indexed | 2024-03-08T20:53:04Z |
| format | Article |
| id | doaj.art-c095ed8040464900adfd3c9670115e16 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-08T20:53:04Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-c095ed8040464900adfd3c9670115e162023-12-22T14:02:01ZengMDPI AGCrystals2073-43522023-12-011312169510.3390/cryst13121695Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for ImplantsAngela Gabriela Păun0Valeria Petrina1Nicoleta Badea2Camelia Ungureanu3Simona Popescu4Cristina Dumitriu5Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, RomaniaThe early loss of dental implants can be avoided with systemic antibiotics, however there are potentially significant side effects. Consequently, the use of local drug administration techniques is necessary to make dental implant therapy more practical. In this study, Y-branched nanotubes were prepared by non-expensive and simple anodization in two steps. Tests were performed to highlight their potential for local antibiotic administration. Y-branched nanotubes were able to incorporate a dose of Tetracycline and ensure its electrochemical stability. The presence of tetracycline significantly enhanced antibacterial efficacy, resulting in an increase of up to 55% for <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> and 50% for <i>Staphylococcus aureus</i>. The comparable antibacterial effects of the nanostructured surfaces highlight the potential of tetracycline in promoting antimicrobial action. Moreover, the addition of tetracycline does not influence the structural, morphological and stability properties of the nanostructured deposited TiO<sub>2</sub> films.https://www.mdpi.com/2073-4352/13/12/1695Y-branched nanotubestetracyclineantibiotic releaseantibacterial effect |
| spellingShingle | Angela Gabriela Păun Valeria Petrina Nicoleta Badea Camelia Ungureanu Simona Popescu Cristina Dumitriu Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants Crystals Y-branched nanotubes tetracycline antibiotic release antibacterial effect |
| title | Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants |
| title_full | Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants |
| title_fullStr | Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants |
| title_full_unstemmed | Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants |
| title_short | Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants |
| title_sort | y branched titanium dioxide nanotubes as a potential antimicrobial coating for implants |
| topic | Y-branched nanotubes tetracycline antibiotic release antibacterial effect |
| url | https://www.mdpi.com/2073-4352/13/12/1695 |
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