Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities
Obesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle alteration or surgery represents the main modality to combat obesit...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/7/1445 |
| _version_ | 1797416467857145856 |
|---|---|
| author | Jing Li Hongli Duan Yan Liu Lu Wang Xing Zhou |
| author_facet | Jing Li Hongli Duan Yan Liu Lu Wang Xing Zhou |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Obesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle alteration or surgery represents the main modality to combat obesity and its complications. However, most anti-obesity drugs are limited by their bioavailability, target specificity, and potential toxic effects. Only a handful of drugs, including orlistat, liraglutide, and semaglutide, are currently approved for clinical obesity treatment. Thus, there is an urgent need for alternative treatment strategies. Based on the new revelation of the pathogenesis of obesity and the efforts toward the multi-disciplinary integration of materials, chemistry, biotechnology, and pharmacy, some emerging obesity treatment strategies are gradually entering the field of preclinical and clinical research. Herein, by analyzing the current situation and challenges of various new obesity treatment strategies such as small-molecule drugs, natural drugs, and biotechnology drugs, the advanced functions and prospects of biomaterials in obesity-targeted delivery, as well as their biological activities and applications in obesity treatment, are systematically summarized. Finally, based on the systematic analysis of biomaterial-based obesity therapeutic strategies, the future prospects and challenges in this field are proposed. |
| first_indexed | 2024-03-09T06:04:41Z |
| format | Article |
| id | doaj.art-c098c70aa6e64bb0bd20a8156405becd |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T06:04:41Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c098c70aa6e64bb0bd20a8156405becd2023-12-03T12:06:13ZengMDPI AGPharmaceutics1999-49232022-07-01147144510.3390/pharmaceutics14071445Biomaterial-Based Therapeutic Strategies for Obesity and Its ComorbiditiesJing Li0Hongli Duan1Yan Liu2Lu Wang3Xing Zhou4School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaObesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle alteration or surgery represents the main modality to combat obesity and its complications. However, most anti-obesity drugs are limited by their bioavailability, target specificity, and potential toxic effects. Only a handful of drugs, including orlistat, liraglutide, and semaglutide, are currently approved for clinical obesity treatment. Thus, there is an urgent need for alternative treatment strategies. Based on the new revelation of the pathogenesis of obesity and the efforts toward the multi-disciplinary integration of materials, chemistry, biotechnology, and pharmacy, some emerging obesity treatment strategies are gradually entering the field of preclinical and clinical research. Herein, by analyzing the current situation and challenges of various new obesity treatment strategies such as small-molecule drugs, natural drugs, and biotechnology drugs, the advanced functions and prospects of biomaterials in obesity-targeted delivery, as well as their biological activities and applications in obesity treatment, are systematically summarized. Finally, based on the systematic analysis of biomaterial-based obesity therapeutic strategies, the future prospects and challenges in this field are proposed.https://www.mdpi.com/1999-4923/14/7/1445biomaterialdrug deliveryobesity |
| spellingShingle | Jing Li Hongli Duan Yan Liu Lu Wang Xing Zhou Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities Pharmaceutics biomaterial drug delivery obesity |
| title | Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities |
| title_full | Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities |
| title_fullStr | Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities |
| title_full_unstemmed | Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities |
| title_short | Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities |
| title_sort | biomaterial based therapeutic strategies for obesity and its comorbidities |
| topic | biomaterial drug delivery obesity |
| url | https://www.mdpi.com/1999-4923/14/7/1445 |
| work_keys_str_mv | AT jingli biomaterialbasedtherapeuticstrategiesforobesityanditscomorbidities AT hongliduan biomaterialbasedtherapeuticstrategiesforobesityanditscomorbidities AT yanliu biomaterialbasedtherapeuticstrategiesforobesityanditscomorbidities AT luwang biomaterialbasedtherapeuticstrategiesforobesityanditscomorbidities AT xingzhou biomaterialbasedtherapeuticstrategiesforobesityanditscomorbidities |