High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy
Purpose: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein. Design: Cross-sectional multicenter study. Participants: Patients with CSCR compared...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ophthalmology Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914523000106 |
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| author | Elodie Bousquet, MD, PhD Camille Chenevier-Gobeaux, MD Thara Jaworski Héloïse Torres-Villaros, MD Marta Zola, MD Irmela Mantel, MD Laura Kowalczuk, PhD Alexandre Matet, MD, PhD Alejandra Daruich, MD, PhD Min Zhao, MD, PhD Suzanne Yzer, MD Francine Behar-Cohen, MD, PhD |
| author_facet | Elodie Bousquet, MD, PhD Camille Chenevier-Gobeaux, MD Thara Jaworski Héloïse Torres-Villaros, MD Marta Zola, MD Irmela Mantel, MD Laura Kowalczuk, PhD Alexandre Matet, MD, PhD Alejandra Daruich, MD, PhD Min Zhao, MD, PhD Suzanne Yzer, MD Francine Behar-Cohen, MD, PhD |
| author_sort | Elodie Bousquet, MD, PhD |
| collection | DOAJ |
| description | Purpose: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein. Design: Cross-sectional multicenter study. Participants: Patients with CSCR compared with age- and sex-matched healthy participants. Methods: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum. Main Outcome Measures: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants. Results: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR. Conclusions: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. |
| first_indexed | 2024-03-11T21:15:17Z |
| format | Article |
| id | doaj.art-c09a0a7104364e1996c3b817746fdebc |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-03-11T21:15:17Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-c09a0a7104364e1996c3b817746fdebc2023-09-29T04:45:17ZengElsevierOphthalmology Science2666-91452023-09-0133100278High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous ChorioretinopathyElodie Bousquet, MD, PhD0Camille Chenevier-Gobeaux, MD1Thara Jaworski2Héloïse Torres-Villaros, MD3Marta Zola, MD4Irmela Mantel, MD5Laura Kowalczuk, PhD6Alexandre Matet, MD, PhD7Alejandra Daruich, MD, PhD8Min Zhao, MD, PhD9Suzanne Yzer, MD10Francine Behar-Cohen, MD, PhD11Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, FranceService de diagnostic biologique automatisé, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, FranceCentre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, FranceDepartment of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, FranceDepartment of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, FranceDepartment of Ophthalmology, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, SwitzerlandDepartment of Ophthalmology, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, SwitzerlandDepartment of Ophthalmology, Institut Curie, University of Paris Cité, Paris, FranceCentre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France; Department of Ophthalmology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, FranceCentre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, FranceDepartment of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the NetherlandsDepartment of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France; Correspondence: Francine Behar-Cohen, MD, PhD, centre de recherche des cordeliers, 15 rue de l’école de médecine, 75006 Paris, France.Purpose: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein. Design: Cross-sectional multicenter study. Participants: Patients with CSCR compared with age- and sex-matched healthy participants. Methods: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum. Main Outcome Measures: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants. Results: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR. Conclusions: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.http://www.sciencedirect.com/science/article/pii/S2666914523000106C-reactive proteinCentral serous chorioretinopathyGlucocorticoidInflammation, Pentraxin 3 |
| spellingShingle | Elodie Bousquet, MD, PhD Camille Chenevier-Gobeaux, MD Thara Jaworski Héloïse Torres-Villaros, MD Marta Zola, MD Irmela Mantel, MD Laura Kowalczuk, PhD Alexandre Matet, MD, PhD Alejandra Daruich, MD, PhD Min Zhao, MD, PhD Suzanne Yzer, MD Francine Behar-Cohen, MD, PhD High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy Ophthalmology Science C-reactive protein Central serous chorioretinopathy Glucocorticoid Inflammation, Pentraxin 3 |
| title | High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy |
| title_full | High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy |
| title_fullStr | High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy |
| title_full_unstemmed | High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy |
| title_short | High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy |
| title_sort | high levels of c reactive protein with low levels of pentraxin 3 as biomarkers for central serous chorioretinopathy |
| topic | C-reactive protein Central serous chorioretinopathy Glucocorticoid Inflammation, Pentraxin 3 |
| url | http://www.sciencedirect.com/science/article/pii/S2666914523000106 |
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