Brain structure and function changes in inflammatory bowel disease
As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease (IBD) continues to evolve, a greater understanding of brain structure and functional connectivity (FC) is necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Neuroimage: Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956022000216 |
| _version_ | 1818208847688368128 |
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| author | Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein |
| author_facet | Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein |
| author_sort | Jennifer Kornelsen |
| collection | DOAJ |
| description | As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease (IBD) continues to evolve, a greater understanding of brain structure and functional connectivity (FC) is necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structure and in FC of brain regions in 111 participants with IBD (76 ulcerative colitis (UC) and 35 Crohn's disease (CD)) and 74 healthy controls (HC). Significant differences between IBD and HC were observed in the three analyses used (voxel based morphometry, region-of-interest, and independent component analysis) in brain regions of the default mode, cerebellar, and visual networks. Significant differences between IBD subtypes (UC, CD) were found. The results of the current study establish that a relationship between brain functional connectivity and the brain-gut axis exists in IBD. |
| first_indexed | 2024-12-12T04:51:19Z |
| format | Article |
| id | doaj.art-c09a4fb58af149668b4a677188b222bd |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-12-12T04:51:19Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-c09a4fb58af149668b4a677188b222bd2022-12-22T00:37:28ZengElsevierNeuroimage: Reports2666-95602022-06-0122100097Brain structure and function changes in inflammatory bowel diseaseJennifer Kornelsen0Kelcie Witges1Jennifer Labus2Emeran A. Mayer3Charles N. Bernstein4University of Manitoba, Department of Radiology, Winnipeg, Manitoba, Canada; University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada; Corresponding author. Department of Radiology, University of Manitoba SR226 Kleysen Institute for Advanced Medicine, 710 William Avenue, Winnipeg, MB R2H 2A6, Canada.University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, CanadaG. Oppenheimer Family Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAG. Oppenheimer Family Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAUniversity of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada; University of Manitoba, Department of Internal Medicine, Winnipeg, Manitoba, CanadaAs the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease (IBD) continues to evolve, a greater understanding of brain structure and functional connectivity (FC) is necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structure and in FC of brain regions in 111 participants with IBD (76 ulcerative colitis (UC) and 35 Crohn's disease (CD)) and 74 healthy controls (HC). Significant differences between IBD and HC were observed in the three analyses used (voxel based morphometry, region-of-interest, and independent component analysis) in brain regions of the default mode, cerebellar, and visual networks. Significant differences between IBD subtypes (UC, CD) were found. The results of the current study establish that a relationship between brain functional connectivity and the brain-gut axis exists in IBD.http://www.sciencedirect.com/science/article/pii/S2666956022000216Inflammatory bowel disease (IBD)Ulcerative colitis (UC)Crohn's disease (CD)Resting state networks (RSN)Functional connectivity (FC)Functional magnetic resonance imaging (fMRI) |
| spellingShingle | Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein Brain structure and function changes in inflammatory bowel disease Neuroimage: Reports Inflammatory bowel disease (IBD) Ulcerative colitis (UC) Crohn's disease (CD) Resting state networks (RSN) Functional connectivity (FC) Functional magnetic resonance imaging (fMRI) |
| title | Brain structure and function changes in inflammatory bowel disease |
| title_full | Brain structure and function changes in inflammatory bowel disease |
| title_fullStr | Brain structure and function changes in inflammatory bowel disease |
| title_full_unstemmed | Brain structure and function changes in inflammatory bowel disease |
| title_short | Brain structure and function changes in inflammatory bowel disease |
| title_sort | brain structure and function changes in inflammatory bowel disease |
| topic | Inflammatory bowel disease (IBD) Ulcerative colitis (UC) Crohn's disease (CD) Resting state networks (RSN) Functional connectivity (FC) Functional magnetic resonance imaging (fMRI) |
| url | http://www.sciencedirect.com/science/article/pii/S2666956022000216 |
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