Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study
Objective: The objective of this study was to investigate spinal radiographic progression in specific age ranges of ankylosing spondylitis (AS) patients. Methods: Longitudinal data for 1125 AS patients at a single hospital from 2000 to 2018 were retrospectively reviewed. Radiographic intervals were...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Therapeutic Advances in Musculoskeletal Disease |
| Online Access: | https://doi.org/10.1177/1759720X221100301 |
| _version_ | 1811335579238924288 |
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| author | Tae-Han Lee Bon San Koo Bora Nam Yun Jin Kim Donghee Son Seunghun Lee Kyung Bin Joo Tae-Hwan Kim |
| author_facet | Tae-Han Lee Bon San Koo Bora Nam Yun Jin Kim Donghee Son Seunghun Lee Kyung Bin Joo Tae-Hwan Kim |
| author_sort | Tae-Han Lee |
| collection | DOAJ |
| description | Objective: The objective of this study was to investigate spinal radiographic progression in specific age ranges of ankylosing spondylitis (AS) patients. Methods: Longitudinal data for 1125 AS patients at a single hospital from 2000 to 2018 were retrospectively reviewed. Radiographic intervals were obtained from patients with consecutive spinal radiographs. The radiographic progression rate was defined as the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) change per year within each interval. Using generalized estimating equations (GEEs), estimated marginal means were calculated for the mSASSS progression rate across age groups after adjusting for potential confounders. Results: We obtained 4016 radiographic intervals and stratified them into five groups based on patient age at the interval start: <20 ( n = 122); 20–29 ( n = 1124); 30–39 ( n = 1690); 40–49 ( n = 794); and ⩾50 years ( n = 286). The mean (SD) mSASSS progression rate for all the intervals was 0.8 (1.9). The GEE-estimated mean mSASSS progression rate increased with age, peaking in the 30–39 age group with a value of 1.15 [95% confidence interval (CI) 1.03, 1.27], and decreased slightly thereafter. In the presence of risk factors, rapid progression occurred at earlier ages: the GEE-estimated mean mSASSS progression rate in those with elevated C-reactive protein levels and preexisting syndesmophytes was 2.82 (95% CI 1.93, 3.71) in the 20–29 age group. Conclusion: Spinal structural damage in AS seems to progress most rapidly when patients are age 30–39 years. An awareness of the trends in radiographic progression with advancing age could improve understanding of the natural course of AS. |
| first_indexed | 2024-04-13T17:26:19Z |
| format | Article |
| id | doaj.art-c09a9fa265d34e1b84729e6528ff5886 |
| institution | Directory Open Access Journal |
| issn | 1759-7218 |
| language | English |
| last_indexed | 2024-04-13T17:26:19Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Musculoskeletal Disease |
| spelling | doaj.art-c09a9fa265d34e1b84729e6528ff58862022-12-22T02:37:46ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182022-05-011410.1177/1759720X221100301Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal studyTae-Han LeeBon San KooBora NamYun Jin KimDonghee SonSeunghun LeeKyung Bin JooTae-Hwan KimObjective: The objective of this study was to investigate spinal radiographic progression in specific age ranges of ankylosing spondylitis (AS) patients. Methods: Longitudinal data for 1125 AS patients at a single hospital from 2000 to 2018 were retrospectively reviewed. Radiographic intervals were obtained from patients with consecutive spinal radiographs. The radiographic progression rate was defined as the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) change per year within each interval. Using generalized estimating equations (GEEs), estimated marginal means were calculated for the mSASSS progression rate across age groups after adjusting for potential confounders. Results: We obtained 4016 radiographic intervals and stratified them into five groups based on patient age at the interval start: <20 ( n = 122); 20–29 ( n = 1124); 30–39 ( n = 1690); 40–49 ( n = 794); and ⩾50 years ( n = 286). The mean (SD) mSASSS progression rate for all the intervals was 0.8 (1.9). The GEE-estimated mean mSASSS progression rate increased with age, peaking in the 30–39 age group with a value of 1.15 [95% confidence interval (CI) 1.03, 1.27], and decreased slightly thereafter. In the presence of risk factors, rapid progression occurred at earlier ages: the GEE-estimated mean mSASSS progression rate in those with elevated C-reactive protein levels and preexisting syndesmophytes was 2.82 (95% CI 1.93, 3.71) in the 20–29 age group. Conclusion: Spinal structural damage in AS seems to progress most rapidly when patients are age 30–39 years. An awareness of the trends in radiographic progression with advancing age could improve understanding of the natural course of AS.https://doi.org/10.1177/1759720X221100301 |
| spellingShingle | Tae-Han Lee Bon San Koo Bora Nam Yun Jin Kim Donghee Son Seunghun Lee Kyung Bin Joo Tae-Hwan Kim Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study Therapeutic Advances in Musculoskeletal Disease |
| title | Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study |
| title_full | Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study |
| title_fullStr | Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study |
| title_full_unstemmed | Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study |
| title_short | Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study |
| title_sort | age stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis a longitudinal study |
| url | https://doi.org/10.1177/1759720X221100301 |
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