Targeting Wnt/β-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation

Targeting Wnt/β-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation

Approximately 50% of coronary artery bypass grafts using the autologous saphenous vein fail within 10 years due to intimal thickening. This study examined whether a gene therapy approach that selectively kills Wnt/β-catenin/T cell factor (TCF) activated vascular smooth muscle cells (VSMCs) using dom...

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Bibliographic Details
Main Authors: Sarah Hulin-Curtis, Helen Williams, Kerry S. Wadey, Graciela B. Sala-Newby, Sarah J. George
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vein graft failure
apoptosis
vascular smooth muscle cell
gene therapy
cadherin
intimal thickening
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300645

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