Central nervous system manifestations in rheumatic diseases
Neurological involvement is associated with significant morbidity in patients with rheumatic diseases, and may indicate heightened disease activity. Connective tissue diseases result from immunologic or autoimmune reactions. However, involvement of the central nervous system (CNS) may be a striking...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2011-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101001C.pdf |
| _version_ | 1818326626087206912 |
|---|---|
| author | Cojocaru Mihaela Inimioara Cojocaru Manole Silosi Isabela Vrabie Doina Camelia |
| author_facet | Cojocaru Mihaela Inimioara Cojocaru Manole Silosi Isabela Vrabie Doina Camelia |
| author_sort | Cojocaru Mihaela Inimioara |
| collection | DOAJ |
| description | Neurological involvement is associated with significant morbidity in patients with rheumatic diseases, and may indicate heightened disease activity. Connective tissue diseases result from immunologic or autoimmune reactions. However, involvement of the central nervous system (CNS) may be a striking early or presenting feature with a wide variety of manifestations. Summary: Patients with multi-system rheumatic conditions may have a disease affecting the central nervous system (CNS). Central nervous system manifestations vary according to the location of the lesion and range from focal findings (e.g., stroke-like presentations), although serious neurological complications in rheumatic disease appear to be rare. The most prominent features of neurological involvement in rheumatic diseases include cerebral ischaemia and psychiatric symptoms. Little information is available on the prevalence of neurological disease in patients with a rheumatological diagnosis. Involvement of the CNS may be a striking early or presenting feature with a wide variety of manifestations. There is more clarity about the CNS syndromes attributable to systemic lupus erythematosus and new insights into the central mechanisms involved in the manifestations of Sjögren's syndrome and rheumatoid arthritis. Severe CNS involvement is associated with poor prognosis, and high mortality rate. We review the spectrum of neurological diseases in patients with a rheumatological diagnosis. . |
| first_indexed | 2024-12-13T12:03:22Z |
| format | Article |
| id | doaj.art-c09d5ba5d1404386b8fff2685a2c5917 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-13T12:03:22Z |
| publishDate | 2011-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-c09d5ba5d1404386b8fff2685a2c59172022-12-21T23:47:02ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662011-01-01301141452-82581101001CCentral nervous system manifestations in rheumatic diseasesCojocaru Mihaela Inimioara0Cojocaru Manole1Silosi Isabela2Vrabie Doina Camelia3'Carol Davila' University of Medicine and Pharmacy, 'Prof. Gheorghe Marinescu' Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania'Titu Maiorescu' University, Faculty of Medicine, Discipline of Physiology, 'Dr. Ion Stoia' Center for Rheumatic Diseases, Bucharest, RomaniaUniversity of Medicine and Pharmacy, Faculty of Medicine, Discipline of Immunology, Craiova, Romania'Carol Davila' University of Medicine and Pharmacy, Clinical Hospital of Emergency 'Sfantul Ioan', 'Victor Babes' National Institute for Pathology and Biomedical Sciences, Bucharest, RomaniaNeurological involvement is associated with significant morbidity in patients with rheumatic diseases, and may indicate heightened disease activity. Connective tissue diseases result from immunologic or autoimmune reactions. However, involvement of the central nervous system (CNS) may be a striking early or presenting feature with a wide variety of manifestations. Summary: Patients with multi-system rheumatic conditions may have a disease affecting the central nervous system (CNS). Central nervous system manifestations vary according to the location of the lesion and range from focal findings (e.g., stroke-like presentations), although serious neurological complications in rheumatic disease appear to be rare. The most prominent features of neurological involvement in rheumatic diseases include cerebral ischaemia and psychiatric symptoms. Little information is available on the prevalence of neurological disease in patients with a rheumatological diagnosis. Involvement of the CNS may be a striking early or presenting feature with a wide variety of manifestations. There is more clarity about the CNS syndromes attributable to systemic lupus erythematosus and new insights into the central mechanisms involved in the manifestations of Sjögren's syndrome and rheumatoid arthritis. Severe CNS involvement is associated with poor prognosis, and high mortality rate. We review the spectrum of neurological diseases in patients with a rheumatological diagnosis. .https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101001C.pdfneurological complicationsrheumatic diseases |
| spellingShingle | Cojocaru Mihaela Inimioara Cojocaru Manole Silosi Isabela Vrabie Doina Camelia Central nervous system manifestations in rheumatic diseases Journal of Medical Biochemistry neurological complications rheumatic diseases |
| title | Central nervous system manifestations in rheumatic diseases |
| title_full | Central nervous system manifestations in rheumatic diseases |
| title_fullStr | Central nervous system manifestations in rheumatic diseases |
| title_full_unstemmed | Central nervous system manifestations in rheumatic diseases |
| title_short | Central nervous system manifestations in rheumatic diseases |
| title_sort | central nervous system manifestations in rheumatic diseases |
| topic | neurological complications rheumatic diseases |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101001C.pdf |
| work_keys_str_mv | AT cojocarumihaelainimioara centralnervoussystemmanifestationsinrheumaticdiseases AT cojocarumanole centralnervoussystemmanifestationsinrheumaticdiseases AT silosiisabela centralnervoussystemmanifestationsinrheumaticdiseases AT vrabiedoinacamelia centralnervoussystemmanifestationsinrheumaticdiseases |