Regioselective Reaction of 2-Indolylmethanols with Enamides
A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl<sub>3</sub> as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3341 |
| _version_ | 1827744308498792448 |
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| author | Yuting Tian Dongqing He Limei Gao Yu Zou Xiaoshuang Liu Qiang Wang Enxiang Liang Yongsheng Zheng |
| author_facet | Yuting Tian Dongqing He Limei Gao Yu Zou Xiaoshuang Liu Qiang Wang Enxiang Liang Yongsheng Zheng |
| author_sort | Yuting Tian |
| collection | DOAJ |
| description | A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl<sub>3</sub> as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids. |
| first_indexed | 2024-03-11T04:42:51Z |
| format | Article |
| id | doaj.art-c09dedd46e9c452598f9a45e2f92ae09 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:42:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c09dedd46e9c452598f9a45e2f92ae092023-11-17T20:37:36ZengMDPI AGMolecules1420-30492023-04-01288334110.3390/molecules28083341Regioselective Reaction of 2-Indolylmethanols with EnamidesYuting Tian0Dongqing He1Limei Gao2Yu Zou3Xiaoshuang Liu4Qiang Wang5Enxiang Liang6Yongsheng Zheng7School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaDepartment of Chemistry and Chemical Engineering, Institute of Science and Technology, Yueyang 414000, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaDepartment of Chemistry and Chemical Engineering, Institute of Science and Technology, Yueyang 414000, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaA highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl<sub>3</sub> as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.https://www.mdpi.com/1420-3049/28/8/33412-indolylmethanolsenamidesregioselectiveadditionhybrid |
| spellingShingle | Yuting Tian Dongqing He Limei Gao Yu Zou Xiaoshuang Liu Qiang Wang Enxiang Liang Yongsheng Zheng Regioselective Reaction of 2-Indolylmethanols with Enamides Molecules 2-indolylmethanols enamides regioselective addition hybrid |
| title | Regioselective Reaction of 2-Indolylmethanols with Enamides |
| title_full | Regioselective Reaction of 2-Indolylmethanols with Enamides |
| title_fullStr | Regioselective Reaction of 2-Indolylmethanols with Enamides |
| title_full_unstemmed | Regioselective Reaction of 2-Indolylmethanols with Enamides |
| title_short | Regioselective Reaction of 2-Indolylmethanols with Enamides |
| title_sort | regioselective reaction of 2 indolylmethanols with enamides |
| topic | 2-indolylmethanols enamides regioselective addition hybrid |
| url | https://www.mdpi.com/1420-3049/28/8/3341 |
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