Drug-Associated Gastropathy: Diagnostic Criteria
Drugs are widely used to treat different diseases in modern medicine, but they are often associated with adverse events. Those located in the gastrointestinal tract are common and often mild, but they can be serious or life-threatening and determine the continuation of treatment. The stomach is ofte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/13/2220 |
| _version_ | 1797591922757337088 |
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| author | Dmitry S. Bordin Maria A. Livzan Olga V. Gaus Sergei I. Mozgovoi Angel Lanas |
| author_facet | Dmitry S. Bordin Maria A. Livzan Olga V. Gaus Sergei I. Mozgovoi Angel Lanas |
| author_sort | Dmitry S. Bordin |
| collection | DOAJ |
| description | Drugs are widely used to treat different diseases in modern medicine, but they are often associated with adverse events. Those located in the gastrointestinal tract are common and often mild, but they can be serious or life-threatening and determine the continuation of treatment. The stomach is often affected not only by drugs taken orally but also by those administered parenterally. Here, we review the mechanisms of damage, risk factors and specific endoscopic, histopathological and clinical features of those drugs more often involved in gastric damage, namely NSAIDs, aspirin, anticoagulants, glucocorticosteroids, anticancer drugs, oral iron preparations and proton pump inhibitors. NSAID- and aspirin-associated forms of gastric damage are widely studied and have specific features, although they are often hidden by the coexistence of <i>Helicobacter pylori</i> infection. However, the damaging effect of anticoagulants and corticosteroids or oral iron therapy on the gastric mucosa is controversial. At the same time, the increased use of new antineoplastic drugs, such as checkpoint inhibitors, has opened up a new area of gastrointestinal damage that will be seen more frequently in the near future. We conclude that there is a need to expand and understand drug-induced gastrointestinal damage to prevent and recognize drug-associated gastropathy in a timely manner. |
| first_indexed | 2024-03-11T01:44:27Z |
| format | Article |
| id | doaj.art-c09f3652a916467498fcf6fd6b576e82 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:44:27Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c09f3652a916467498fcf6fd6b576e822023-11-18T16:21:44ZengMDPI AGDiagnostics2075-44182023-06-011313222010.3390/diagnostics13132220Drug-Associated Gastropathy: Diagnostic CriteriaDmitry S. Bordin0Maria A. Livzan1Olga V. Gaus2Sergei I. Mozgovoi3Angel Lanas4A.S. Loginov Moscow Clinical Scientific Center, Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, 111123 Moscow, RussiaDepartment of Faculty Therapy and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Faculty Therapy and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, RussiaDigestive Diseases Service, Aragón Health Research Institute (IIS Aragón), University Clinic Hospital, University of Zaragoza, 50009 Zaragoza, SpainDrugs are widely used to treat different diseases in modern medicine, but they are often associated with adverse events. Those located in the gastrointestinal tract are common and often mild, but they can be serious or life-threatening and determine the continuation of treatment. The stomach is often affected not only by drugs taken orally but also by those administered parenterally. Here, we review the mechanisms of damage, risk factors and specific endoscopic, histopathological and clinical features of those drugs more often involved in gastric damage, namely NSAIDs, aspirin, anticoagulants, glucocorticosteroids, anticancer drugs, oral iron preparations and proton pump inhibitors. NSAID- and aspirin-associated forms of gastric damage are widely studied and have specific features, although they are often hidden by the coexistence of <i>Helicobacter pylori</i> infection. However, the damaging effect of anticoagulants and corticosteroids or oral iron therapy on the gastric mucosa is controversial. At the same time, the increased use of new antineoplastic drugs, such as checkpoint inhibitors, has opened up a new area of gastrointestinal damage that will be seen more frequently in the near future. We conclude that there is a need to expand and understand drug-induced gastrointestinal damage to prevent and recognize drug-associated gastropathy in a timely manner.https://www.mdpi.com/2075-4418/13/13/2220gastritisdrug-induced gastric damageNSAIDsaspirinanticoagulantsmycophenolate |
| spellingShingle | Dmitry S. Bordin Maria A. Livzan Olga V. Gaus Sergei I. Mozgovoi Angel Lanas Drug-Associated Gastropathy: Diagnostic Criteria Diagnostics gastritis drug-induced gastric damage NSAIDs aspirin anticoagulants mycophenolate |
| title | Drug-Associated Gastropathy: Diagnostic Criteria |
| title_full | Drug-Associated Gastropathy: Diagnostic Criteria |
| title_fullStr | Drug-Associated Gastropathy: Diagnostic Criteria |
| title_full_unstemmed | Drug-Associated Gastropathy: Diagnostic Criteria |
| title_short | Drug-Associated Gastropathy: Diagnostic Criteria |
| title_sort | drug associated gastropathy diagnostic criteria |
| topic | gastritis drug-induced gastric damage NSAIDs aspirin anticoagulants mycophenolate |
| url | https://www.mdpi.com/2075-4418/13/13/2220 |
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