Synthesis of cyclic N1-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells

Synthesis of cyclic N1-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells

Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was synthesized. The role played by the position of the...

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Bibliographic Details
Main Authors: Ahmed Mahal, Stefano D’Errico, Nicola Borbone, Brunella Pinto, Agnese Secondo, Valeria Costantino, Valentina Tedeschi, Giorgia Oliviero, Vincenzo Piccialli, Gennaro Piccialli
Format: Article
Language:English
Published: Beilstein-Institut 2015-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
calcium mobilization
cIDPR analogues
cyclic ADP-ribose (cADPR)
cyclization
Online Access:https://doi.org/10.3762/bjoc.11.289

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