Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats
Aconitase 1 (ACO1) links oxidative stress and iron accumulation in Parkinson’s disease (PD). ACO1 loses its aconitase activity and turns into iron regulatory protein 1 (IRP1) upon oxidative stress. IRP1 plays an important role in the accumulation of intracellular iron. Baicalein is a flavonoid isola...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/1/12 |
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| author | Run-Zhe Liu Sen Zhang Wen Zhang Xiao-Yue Zhao Guan-Hua Du |
| author_facet | Run-Zhe Liu Sen Zhang Wen Zhang Xiao-Yue Zhao Guan-Hua Du |
| author_sort | Run-Zhe Liu |
| collection | DOAJ |
| description | Aconitase 1 (ACO1) links oxidative stress and iron accumulation in Parkinson’s disease (PD). ACO1 loses its aconitase activity and turns into iron regulatory protein 1 (IRP1) upon oxidative stress. IRP1 plays an important role in the accumulation of intracellular iron. Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis. The present results show that baicalein could bind to ACO1 and protect its isoform from the oxidative stress induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Furthermore, baicalein promoted aconitase activity and inhibited IRP1 activation in rotenone-induced PD models. Additionally, baicalein decreased the hydroxyl radicals generated by iron. In conclusion, baicalein attenuated iron accumulation and iron-induced oxidative stress in the brain of PD rats by protecting ACO1. |
| first_indexed | 2024-03-09T13:47:29Z |
| format | Article |
| id | doaj.art-c0a228e1c0164f5a8d993f76f4fa49dc |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:47:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c0a228e1c0164f5a8d993f76f4fa49dc2023-11-30T20:57:05ZengMDPI AGAntioxidants2076-39212022-12-011211210.3390/antiox12010012Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in RatsRun-Zhe Liu0Sen Zhang1Wen Zhang2Xiao-Yue Zhao3Guan-Hua Du4State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaAconitase 1 (ACO1) links oxidative stress and iron accumulation in Parkinson’s disease (PD). ACO1 loses its aconitase activity and turns into iron regulatory protein 1 (IRP1) upon oxidative stress. IRP1 plays an important role in the accumulation of intracellular iron. Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis. The present results show that baicalein could bind to ACO1 and protect its isoform from the oxidative stress induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Furthermore, baicalein promoted aconitase activity and inhibited IRP1 activation in rotenone-induced PD models. Additionally, baicalein decreased the hydroxyl radicals generated by iron. In conclusion, baicalein attenuated iron accumulation and iron-induced oxidative stress in the brain of PD rats by protecting ACO1.https://www.mdpi.com/2076-3921/12/1/12baicaleinAconitase 1 (ACO1)iron regulatory protein 1 (IRP1)Parkinson’s diseaseiron accumulation |
| spellingShingle | Run-Zhe Liu Sen Zhang Wen Zhang Xiao-Yue Zhao Guan-Hua Du Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats Antioxidants baicalein Aconitase 1 (ACO1) iron regulatory protein 1 (IRP1) Parkinson’s disease iron accumulation |
| title | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats |
| title_full | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats |
| title_fullStr | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats |
| title_full_unstemmed | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats |
| title_short | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats |
| title_sort | baicalein attenuates brain iron accumulation through protecting aconitase 1 from oxidative stress in rotenone induced parkinson s disease in rats |
| topic | baicalein Aconitase 1 (ACO1) iron regulatory protein 1 (IRP1) Parkinson’s disease iron accumulation |
| url | https://www.mdpi.com/2076-3921/12/1/12 |
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