Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats

Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats

Aconitase 1 (ACO1) links oxidative stress and iron accumulation in Parkinson’s disease (PD). ACO1 loses its aconitase activity and turns into iron regulatory protein 1 (IRP1) upon oxidative stress. IRP1 plays an important role in the accumulation of intracellular iron. Baicalein is a flavonoid isola...

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Bibliographic Details
Main Authors:	Run-Zhe Liu, Sen Zhang, Wen Zhang, Xiao-Yue Zhao, Guan-Hua Du
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Antioxidants
Subjects:	baicalein Aconitase 1 (ACO1) iron regulatory protein 1 (IRP1) Parkinson’s disease iron accumulation
Online Access:	https://www.mdpi.com/2076-3921/12/1/12

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