Left heart dimensions in anemic cats and dogs before and after blood transfusion
Abstract Background Whether anemic cats and dogs with increased left heart dimensions are at higher risk of transfusion‐associated circulatory overload, and the effect of blood transfusion on left heart dimensions in naturally occurring anemia is unknown. Hypothesis/objectives To evaluate the effect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15969 |
| _version_ | 1798030143631917056 |
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| author | Rebekah E. Donaldson Joonbum Seo Virginia Luis Fuentes Karen Humm |
| author_facet | Rebekah E. Donaldson Joonbum Seo Virginia Luis Fuentes Karen Humm |
| author_sort | Rebekah E. Donaldson |
| collection | DOAJ |
| description | Abstract Background Whether anemic cats and dogs with increased left heart dimensions are at higher risk of transfusion‐associated circulatory overload, and the effect of blood transfusion on left heart dimensions in naturally occurring anemia is unknown. Hypothesis/objectives To evaluate the effect of blood transfusion on left heart dimensions in clinically relevant anemia. Animals Twenty dogs and 20 cats presenting to a university veterinary teaching hospital. Methods In this prospective observational study, anemic dogs and cats requiring blood transfusion were included. Packed cell volume (PCV), total solids, and echocardiography were performed before and within 24 hours of blood transfusion. Signalment, bodyweight, disease process, transfusion duration and volume, and prior treatments were recorded. Nonparametric statistics were reported as median [range]. Post hoc Bonferroni correction set significance at P < .006. Results After transfusion, PCV increased in cats (12% [6–16] to 18% [10‐33], P = .001) and dogs (14% [7–24] to 25% [9‐37], P = .001), heart rate decreased in dogs (104 bpm [86‐166] to 87 bpm [56‐138], P < .001), and fractional shortening decreased in cats (57.1% [36.0‐84.7] to 41.0% [28.1‐69.6], P = .002) and dogs (33.79% [19.33‐62.79] to 31.89% [19.06‐51.47], P = .006). Left ventricular internal diameter in systole increased in cats (6.5 mm [2.7‐9.8] to 7.9 mm [5.3‐11.1], P = .001). Normalized left ventricular internal diameter in diastole (1.48 [1.25‐1.79] to 1.57 [1.33‐2.00], P = .001) and systole (0.87 [0.58‐1.19] to 1.00 [0.74‐1.36], P = .001) increased in dogs. Incidence of volume overload did not differ before (14/20 cats, 70%; 9/20 dogs, 45%) or after (12/20 cats, 60%; 11/20 dogs, 55%) transfusion (P = .64). Conclusions and clinical importance Blood transfusion is well tolerated when signs of volume overload are present before transfusion. |
| first_indexed | 2024-04-11T19:36:37Z |
| format | Article |
| id | doaj.art-c0a26c909cd34da484d732ddabe2b45d |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T19:36:37Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-c0a26c909cd34da484d732ddabe2b45d2022-12-22T04:06:51ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-01-01351435010.1111/jvim.15969Left heart dimensions in anemic cats and dogs before and after blood transfusionRebekah E. Donaldson0Joonbum Seo1Virginia Luis Fuentes2Karen Humm3Department of Clinical Science and Services Royal Veterinary College London UKDepartment of Clinical Science and Services Royal Veterinary College London UKDepartment of Clinical Science and Services Royal Veterinary College London UKDepartment of Clinical Science and Services Royal Veterinary College London UKAbstract Background Whether anemic cats and dogs with increased left heart dimensions are at higher risk of transfusion‐associated circulatory overload, and the effect of blood transfusion on left heart dimensions in naturally occurring anemia is unknown. Hypothesis/objectives To evaluate the effect of blood transfusion on left heart dimensions in clinically relevant anemia. Animals Twenty dogs and 20 cats presenting to a university veterinary teaching hospital. Methods In this prospective observational study, anemic dogs and cats requiring blood transfusion were included. Packed cell volume (PCV), total solids, and echocardiography were performed before and within 24 hours of blood transfusion. Signalment, bodyweight, disease process, transfusion duration and volume, and prior treatments were recorded. Nonparametric statistics were reported as median [range]. Post hoc Bonferroni correction set significance at P < .006. Results After transfusion, PCV increased in cats (12% [6–16] to 18% [10‐33], P = .001) and dogs (14% [7–24] to 25% [9‐37], P = .001), heart rate decreased in dogs (104 bpm [86‐166] to 87 bpm [56‐138], P < .001), and fractional shortening decreased in cats (57.1% [36.0‐84.7] to 41.0% [28.1‐69.6], P = .002) and dogs (33.79% [19.33‐62.79] to 31.89% [19.06‐51.47], P = .006). Left ventricular internal diameter in systole increased in cats (6.5 mm [2.7‐9.8] to 7.9 mm [5.3‐11.1], P = .001). Normalized left ventricular internal diameter in diastole (1.48 [1.25‐1.79] to 1.57 [1.33‐2.00], P = .001) and systole (0.87 [0.58‐1.19] to 1.00 [0.74‐1.36], P = .001) increased in dogs. Incidence of volume overload did not differ before (14/20 cats, 70%; 9/20 dogs, 45%) or after (12/20 cats, 60%; 11/20 dogs, 55%) transfusion (P = .64). Conclusions and clinical importance Blood transfusion is well tolerated when signs of volume overload are present before transfusion.https://doi.org/10.1111/jvim.15969euvolemiahemolysishemorrhagehypovolemiaisovolemianormovolemia |
| spellingShingle | Rebekah E. Donaldson Joonbum Seo Virginia Luis Fuentes Karen Humm Left heart dimensions in anemic cats and dogs before and after blood transfusion Journal of Veterinary Internal Medicine euvolemia hemolysis hemorrhage hypovolemia isovolemia normovolemia |
| title | Left heart dimensions in anemic cats and dogs before and after blood transfusion |
| title_full | Left heart dimensions in anemic cats and dogs before and after blood transfusion |
| title_fullStr | Left heart dimensions in anemic cats and dogs before and after blood transfusion |
| title_full_unstemmed | Left heart dimensions in anemic cats and dogs before and after blood transfusion |
| title_short | Left heart dimensions in anemic cats and dogs before and after blood transfusion |
| title_sort | left heart dimensions in anemic cats and dogs before and after blood transfusion |
| topic | euvolemia hemolysis hemorrhage hypovolemia isovolemia normovolemia |
| url | https://doi.org/10.1111/jvim.15969 |
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