Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal...

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Bibliographic Details
Main Authors: Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Aisha Sultana, Ying Cheng, Wei Tong, Jeffery Pu, Teresa Gentile, Shanti Dsouza, Qi Yang, Alaji Bah, Avery August, Mobin Karimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
GVHD after blood transfusion
T cell
GvL
ITK deficiency
Eomesodermin (EOMES)
JAK-STAT signalling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593863/full

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