Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (<b>1</b>), previously described as anti-inflammatory and analgesic prototype. Applyi...

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Bibliographic Details
Main Authors: Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
acylhydrazone
homologation
anti-inflammatory
analgesic
pain
in silico drug-like
Online Access:https://www.mdpi.com/1420-3049/26/16/4828

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