New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System
Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.933901/full |
| _version_ | 1811218659117367296 |
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| author | Taowen Guo Taowen Guo Xiaobo Zhang Yicun Hu Yicun Hu Maoqiang Lin Maoqiang Lin Ruihao Zhang Ruihao Zhang Xiangyi Chen Xiangyi Chen Dechen Yu Dechen Yu Xin Yao Xin Yao Peng Wang Peng Wang Haiyu Zhou Haiyu Zhou Haiyu Zhou |
| author_facet | Taowen Guo Taowen Guo Xiaobo Zhang Yicun Hu Yicun Hu Maoqiang Lin Maoqiang Lin Ruihao Zhang Ruihao Zhang Xiangyi Chen Xiangyi Chen Dechen Yu Dechen Yu Xin Yao Xin Yao Peng Wang Peng Wang Haiyu Zhou Haiyu Zhou Haiyu Zhou |
| author_sort | Taowen Guo |
| collection | DOAJ |
| description | Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the problem. Recently, a novel microsphere-based therapeutic strategy has held promise for IVD regeneration and has yielded encouraging results with in vitro experiments and animal models. With excellent injectability, biocompatibility, and biodegradability, this microsphere carrier allows for targeted delivery and controlled release of drugs, gene regulatory sequences, and other bioactive substances and supports cell implantation and directed differentiation, aiming to improve the disease state of IVD at the source. This review discusses the possible mechanisms of IVDD and the limitations of current therapies, focusing on the application of microsphere delivery systems in IVDD, including targeted delivery of active substances and drugs, cellular therapy, and gene therapy, and attempts to provide a new understanding for the treatment of IVDD. |
| first_indexed | 2024-04-12T07:13:06Z |
| format | Article |
| id | doaj.art-c0a72f20f87441e799e95e59ac9e8260 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T07:13:06Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-c0a72f20f87441e799e95e59ac9e82602022-12-22T03:42:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.933901933901New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery SystemTaowen Guo0Taowen Guo1Xiaobo Zhang2Yicun Hu3Yicun Hu4Maoqiang Lin5Maoqiang Lin6Ruihao Zhang7Ruihao Zhang8Xiangyi Chen9Xiangyi Chen10Dechen Yu11Dechen Yu12Xin Yao13Xin Yao14Peng Wang15Peng Wang16Haiyu Zhou17Haiyu Zhou18Haiyu Zhou19Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, ChinaXigu District People’s Hospital, Lanzhou, ChinaIntervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the problem. Recently, a novel microsphere-based therapeutic strategy has held promise for IVD regeneration and has yielded encouraging results with in vitro experiments and animal models. With excellent injectability, biocompatibility, and biodegradability, this microsphere carrier allows for targeted delivery and controlled release of drugs, gene regulatory sequences, and other bioactive substances and supports cell implantation and directed differentiation, aiming to improve the disease state of IVD at the source. This review discusses the possible mechanisms of IVDD and the limitations of current therapies, focusing on the application of microsphere delivery systems in IVDD, including targeted delivery of active substances and drugs, cellular therapy, and gene therapy, and attempts to provide a new understanding for the treatment of IVDD.https://www.frontiersin.org/articles/10.3389/fbioe.2022.933901/fullintervertebral disc degenerationmechanismmicrospheresdelivery systeminflammationregeneration |
| spellingShingle | Taowen Guo Taowen Guo Xiaobo Zhang Yicun Hu Yicun Hu Maoqiang Lin Maoqiang Lin Ruihao Zhang Ruihao Zhang Xiangyi Chen Xiangyi Chen Dechen Yu Dechen Yu Xin Yao Xin Yao Peng Wang Peng Wang Haiyu Zhou Haiyu Zhou Haiyu Zhou New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System Frontiers in Bioengineering and Biotechnology intervertebral disc degeneration mechanism microspheres delivery system inflammation regeneration |
| title | New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System |
| title_full | New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System |
| title_fullStr | New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System |
| title_full_unstemmed | New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System |
| title_short | New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System |
| title_sort | new hope for treating intervertebral disc degeneration microsphere based delivery system |
| topic | intervertebral disc degeneration mechanism microspheres delivery system inflammation regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.933901/full |
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