Research progress in the mechanism and treatment of osteosarcoma
Abstract. Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer
2023-10-01
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| Colección: | Chinese Medical Journal |
| Acceso en línea: | http://journals.lww.com/10.1097/CM9.0000000000002800 |
| _version_ | 1827791039117656064 |
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| author | Jichao Bian Yang Liu Xiaowei Zhao Chunyang Meng Yuanmin Zhang Yangmiao Duan Guodong Wang Yanjie Yin |
| author_facet | Jichao Bian Yang Liu Xiaowei Zhao Chunyang Meng Yuanmin Zhang Yangmiao Duan Guodong Wang Yanjie Yin |
| author_sort | Jichao Bian |
| collection | DOAJ |
| description | Abstract. Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research. |
| first_indexed | 2024-03-11T17:41:10Z |
| format | Article |
| id | doaj.art-c0a7bbb60f8946ea8b03edeaa33f1f6b |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-11T17:41:10Z |
| publishDate | 2023-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-c0a7bbb60f8946ea8b03edeaa33f1f6b2023-10-18T09:46:52ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-10-01136202412242010.1097/CM9.0000000000002800202310200-00003Research progress in the mechanism and treatment of osteosarcomaJichao Bian0Yang Liu1Xiaowei Zhao2Chunyang Meng3Yuanmin Zhang4Yangmiao Duan5Guodong Wang6Yanjie Yin1 Department of Joint and Sports Medicine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China2 Department of Pathology, The Second People's Hospital Of Jining, Jining, Shandong 272049, China1 Department of Joint and Sports Medicine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China4 Department of Spine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China.1 Department of Joint and Sports Medicine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China3 Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China1 Department of Joint and Sports Medicine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, ChinaAbstract. Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research.http://journals.lww.com/10.1097/CM9.0000000000002800 |
| spellingShingle | Jichao Bian Yang Liu Xiaowei Zhao Chunyang Meng Yuanmin Zhang Yangmiao Duan Guodong Wang Yanjie Yin Research progress in the mechanism and treatment of osteosarcoma Chinese Medical Journal |
| title | Research progress in the mechanism and treatment of osteosarcoma |
| title_full | Research progress in the mechanism and treatment of osteosarcoma |
| title_fullStr | Research progress in the mechanism and treatment of osteosarcoma |
| title_full_unstemmed | Research progress in the mechanism and treatment of osteosarcoma |
| title_short | Research progress in the mechanism and treatment of osteosarcoma |
| title_sort | research progress in the mechanism and treatment of osteosarcoma |
| url | http://journals.lww.com/10.1097/CM9.0000000000002800 |
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