Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series
Abstract Purpose To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs). Methods A retrospective review was performed of 13 patients with OGM treated with CKRT from September 2005 to May 2018 at our institution. Nine patients wer...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | Radiation Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s13014-020-01506-6 |
| _version_ | 1819028644106862592 |
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| author | Jianmin Liu Rafael Rojas Fred C. Lam Farhan A. Mirza Anand Mahadevan Ekkehard M. Kasper |
| author_facet | Jianmin Liu Rafael Rojas Fred C. Lam Farhan A. Mirza Anand Mahadevan Ekkehard M. Kasper |
| author_sort | Jianmin Liu |
| collection | DOAJ |
| description | Abstract Purpose To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs). Methods A retrospective review was performed of 13 patients with OGM treated with CKRT from September 2005 to May 2018 at our institution. Nine patients were treated primarily with CKRT, 3 for residual disease following resection, and 1 for disease recurrence. Results Five patients were treated with stereotactic radiosurgery (SRS), 6 with hypofractionated stereotactic radiotherapy (HSRT), and 2 with fractionated stereotactic radiotherapy (FSRT). The median tumor volume was 8.12 cm3. The median prescribed dose was 14.8 Gy for SRS, 27.3 Gy for HSRT, and 50.2 Gy for FSRT. The median maximal dose delivered was 32.27 Gy. Median post treatment follow-up was 48 months. Twelve of 13 patients yielded a 100% regional control rate with a median tumor volume reduction of 31.7%. Six of the 12 patients had reduced tumor volumes while the other 6 had no changes. The thirteenth patient had significant radiation-induced edema requiring surgical decompression. Twelve patients were alive and neurologically stable at the time of the review. One patient died from pneumonia unrelated to his CKRT treatment. Conclusions CKRT appears to be safe and effective for the treatment of OGMs. |
| first_indexed | 2024-12-21T06:01:38Z |
| format | Article |
| id | doaj.art-c0a95a2ca8784e3fbce556fd7332d2e5 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-21T06:01:38Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-c0a95a2ca8784e3fbce556fd7332d2e52022-12-21T19:13:45ZengBMCRadiation Oncology1748-717X2020-03-0115111010.1186/s13014-020-01506-6Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective seriesJianmin Liu0Rafael Rojas1Fred C. Lam2Farhan A. Mirza3Anand Mahadevan4Ekkehard M. Kasper5Department of Neurosurgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineDepartment of Radiology, Division of Neuroradiology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDivision of Neurosurgery, Department of Surgery, Hamilton General Hospital, McMaster University Faculty of Health SciencesDivision of Neurosurgery, Kentucky Neuroscience Institute, University of KentuckyDepartment of Radiation Oncology, Geisinger Medical GroupDepartment of Radiology, Division of Neuroradiology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolAbstract Purpose To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs). Methods A retrospective review was performed of 13 patients with OGM treated with CKRT from September 2005 to May 2018 at our institution. Nine patients were treated primarily with CKRT, 3 for residual disease following resection, and 1 for disease recurrence. Results Five patients were treated with stereotactic radiosurgery (SRS), 6 with hypofractionated stereotactic radiotherapy (HSRT), and 2 with fractionated stereotactic radiotherapy (FSRT). The median tumor volume was 8.12 cm3. The median prescribed dose was 14.8 Gy for SRS, 27.3 Gy for HSRT, and 50.2 Gy for FSRT. The median maximal dose delivered was 32.27 Gy. Median post treatment follow-up was 48 months. Twelve of 13 patients yielded a 100% regional control rate with a median tumor volume reduction of 31.7%. Six of the 12 patients had reduced tumor volumes while the other 6 had no changes. The thirteenth patient had significant radiation-induced edema requiring surgical decompression. Twelve patients were alive and neurologically stable at the time of the review. One patient died from pneumonia unrelated to his CKRT treatment. Conclusions CKRT appears to be safe and effective for the treatment of OGMs.http://link.springer.com/article/10.1186/s13014-020-01506-6Olfactory groove meningiomasCyberKnife radiotherapyStereotactic radiosurgeryFractionated stereotactic radiotherapy; Hypofractionated stereotactic radiotherapy |
| spellingShingle | Jianmin Liu Rafael Rojas Fred C. Lam Farhan A. Mirza Anand Mahadevan Ekkehard M. Kasper Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series Radiation Oncology Olfactory groove meningiomas CyberKnife radiotherapy Stereotactic radiosurgery Fractionated stereotactic radiotherapy; Hypofractionated stereotactic radiotherapy |
| title | Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series |
| title_full | Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series |
| title_fullStr | Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series |
| title_full_unstemmed | Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series |
| title_short | Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series |
| title_sort | indications feasibility safety and efficacy of cyberknife radiotherapy for the treatment of olfactory groove meningiomas a single institutional retrospective series |
| topic | Olfactory groove meningiomas CyberKnife radiotherapy Stereotactic radiosurgery Fractionated stereotactic radiotherapy; Hypofractionated stereotactic radiotherapy |
| url | http://link.springer.com/article/10.1186/s13014-020-01506-6 |
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