Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study
BackgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.MethodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and lo...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.580545/full |
| _version_ | 1818884257478606848 |
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| author | Qing Wei Yiding Gao Changsong Qi Xing Yuan Jingjing Li Qi Xu Cong Luo Lei Chen Wei Zhuo Zhiyuan Xu Jieer Ying |
| author_facet | Qing Wei Yiding Gao Changsong Qi Xing Yuan Jingjing Li Qi Xu Cong Luo Lei Chen Wei Zhuo Zhiyuan Xu Jieer Ying |
| author_sort | Qing Wei |
| collection | DOAJ |
| description | BackgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.MethodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to estimate Overall survival (OS) and to determine associations with histologic subtypes. In COX proportional hazards regression model–based univariate and multivariate analyses, significant variables for construction of a nomogram were screened out. The nomogram was validated by means of the concordance index (CI), calibration plots, and receiver operating characteristics (ROCs) curves.ResultsA total of 11,363 gastric cancer patients were enrolled. On dividing the patients into SRC, well-to-moderately differentiated (WMD) adenocarcinoma, and poorly differentiated (PD) adenocarcinoma, differences among these subgroups emerged. SRC patients were more likely to occur in female and young patients than other histologic subtypes. Larger tumors, stage T4, and node stage N3 were more likely to be found in the SRC group. The survival for SRC patients was better than non-SRC patients in stage I. Univariate and multivariate analyses identified age, tumor site, larger tumor size, advanced T classification, advanced N classification, advanced TNM stage, and surgery of primary site as independent prognostic indicators. Then an OS nomogram was formulated.ConclusionsSRC had distinct clinicopathological characteristics. The nomogram provided an accurate tool to evaluate the prognosis of SRC. |
| first_indexed | 2024-12-19T15:46:40Z |
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| id | doaj.art-c0aa88d29eae49669bd93e228c52f7b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T15:46:40Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c0aa88d29eae49669bd93e228c52f7b42022-12-21T20:15:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.580545580545Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based StudyQing Wei0Yiding Gao1Changsong Qi2Xing Yuan3Jingjing Li4Qi Xu5Cong Luo6Lei Chen7Wei Zhuo8Zhiyuan Xu9Jieer Ying10Department of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Cell Biology, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Gastric Surgery, Institute of Cancer and Basic Medicine (ICBM), Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, ChinaDepartment of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaBackgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.MethodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to estimate Overall survival (OS) and to determine associations with histologic subtypes. In COX proportional hazards regression model–based univariate and multivariate analyses, significant variables for construction of a nomogram were screened out. The nomogram was validated by means of the concordance index (CI), calibration plots, and receiver operating characteristics (ROCs) curves.ResultsA total of 11,363 gastric cancer patients were enrolled. On dividing the patients into SRC, well-to-moderately differentiated (WMD) adenocarcinoma, and poorly differentiated (PD) adenocarcinoma, differences among these subgroups emerged. SRC patients were more likely to occur in female and young patients than other histologic subtypes. Larger tumors, stage T4, and node stage N3 were more likely to be found in the SRC group. The survival for SRC patients was better than non-SRC patients in stage I. Univariate and multivariate analyses identified age, tumor site, larger tumor size, advanced T classification, advanced N classification, advanced TNM stage, and surgery of primary site as independent prognostic indicators. Then an OS nomogram was formulated.ConclusionsSRC had distinct clinicopathological characteristics. The nomogram provided an accurate tool to evaluate the prognosis of SRC.https://www.frontiersin.org/articles/10.3389/fonc.2021.580545/fullcarcinomasignet ring cellnomogramsstomach neoplasmsprognosis |
| spellingShingle | Qing Wei Yiding Gao Changsong Qi Xing Yuan Jingjing Li Qi Xu Cong Luo Lei Chen Wei Zhuo Zhiyuan Xu Jieer Ying Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study Frontiers in Oncology carcinoma signet ring cell nomograms stomach neoplasms prognosis |
| title | Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study |
| title_full | Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study |
| title_fullStr | Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study |
| title_full_unstemmed | Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study |
| title_short | Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study |
| title_sort | clinicopathological characteristics and prognosis of signet ring gastric cancer a population based study |
| topic | carcinoma signet ring cell nomograms stomach neoplasms prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.580545/full |
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