Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy

Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy

Abstract Osteoarthritis (OA) is an age-related disease characterized by cartilage degeneration. TNFR1-associated death domain protein (TRADD) is a key upstream molecule of TNF-α signals but its role in OA pathogenesis is unknown. This study aimed to verify that whether inhibition of TRADD could prot...

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Bibliographic Details
Main Authors: Kai Sun, Zhou Guo, Jinming Zhang, Liangcai Hou, Shuang Liang, Fan Lu, Genchun Wang, Jingting Xu, Xiong Zhang, Fengjing Guo, Wentao Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01406-0

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