Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model

Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model

There is no approved antiviral therapy for adenovirus (HAdV) ocular infections. Astodrimer sodium (SPL7013) is a polyanionic dendrimer with antiviral activity. The current study evaluated the ocular tolerability and anti-adenoviral efficacy of topical SPL7013 in rabbit ocular models. In a tolerabili...

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Bibliographic Details
Main Authors: Eric G. Romanowski, Kathleen A. Yates, Jeremy R. A. Paull, Graham P. Heery, Robert M. Q. Shanks
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
astodrimer sodium
SPL7013
dendrimer
antiviral
eye
adenovirus
Online Access:https://www.mdpi.com/1420-3049/26/11/3419

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