The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models

The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models

Abstract Creating a cellular model of Alzheimer's disease (AD) that accurately recapitulates disease pathology has been a longstanding challenge. Recent studies showed that human AD neural cells, integrated into three‐dimensional (3D) hydrogel matrix, display key features of AD neuropathology....

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Bibliographic Details
Main Authors: Matthias Hebisch, Stefanie Klostermeier, Katharina Wolf, Aldo R. Boccaccini, Stephan E. Wolf, Rudolph E. Tanzi, Doo Yeon Kim
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
Alzheimer
hydrogel
neurodegeneration
nonclassical crystallization
synthetic extracellular matrix
Online Access:https://doi.org/10.1002/advs.202205037

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