Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia
<p>Abstract</p> <p>Backgroud</p> <p>EBV-associated Gastric Carcinoma (EBVaGC) has a distinct clinical features and its prevalence is variable worldwide.</p> <p>Results</p> <p>To determine the prevalence of EBVaGC in Tunisia, EBV-encoded small RNA...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-11-01
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| Series: | Virology Journal |
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| Online Access: | http://www.virologyj.com/content/8/1/500 |
| _version_ | 1828429883705917440 |
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| author | Gargouri Ali Sellami-Boudawara Tahia Khabir Abdelmajid Miladi-Abdennadher Imen Ayadi Wajdi BenAyed-Guerfali Dorra Mokdad-Gargouri Raja |
| author_facet | Gargouri Ali Sellami-Boudawara Tahia Khabir Abdelmajid Miladi-Abdennadher Imen Ayadi Wajdi BenAyed-Guerfali Dorra Mokdad-Gargouri Raja |
| author_sort | Gargouri Ali |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Backgroud</p> <p>EBV-associated Gastric Carcinoma (EBVaGC) has a distinct clinical features and its prevalence is variable worldwide.</p> <p>Results</p> <p>To determine the prevalence of EBVaGC in Tunisia, EBV-encoded small RNA (EBER) expression was assessed in 81 gastric carcinoma (GC) specimens. The nuclear EBER expression was detected in 12 out of 81 GC cases (14.81%) and concordance between the score range of EBER staining and the number of EBV DNA copies as estimate by QPCR is observed. On the other hand, we found that EBVaGC strongly correlated with age at diagnosis, and weakly with tumor differentiation and venous invasion.</p> <p>Furthermore, the EBVaGC specimens were subjected to determine the EBV DNA polymorphisms. Our results show a unique genetic profile of the EBV strains regarding the A and D types, the F prototype, the retention of <it>Xho</it>I restriction site and the 30 bp del-LMP1 variant. <b><it>According to our previous studies on nasopharyngeal carcinoma (NPC), we suggested that EBV strains associated to GC and NPC shared some similarities in Tunisian patients</it>.</b></p> <p>Conclusion</p> <p>The prevalence of EBVaGC is of 14.81% in the southern Tunisia and that common EBV strain are associated with both NPC and GC which are likely to differ from Asian strains. Our findings support therefore a certain geographical distribution of EBV strains which is not restricted to EBV-associated malignancies.</p> |
| first_indexed | 2024-12-10T17:40:45Z |
| format | Article |
| id | doaj.art-c0b069f921b8418daf70c50ba73733b8 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-10T17:40:45Z |
| publishDate | 2011-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-c0b069f921b8418daf70c50ba73733b82022-12-22T01:39:23ZengBMCVirology Journal1743-422X2011-11-018150010.1186/1743-422X-8-500Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern TunisiaGargouri AliSellami-Boudawara TahiaKhabir AbdelmajidMiladi-Abdennadher ImenAyadi WajdiBenAyed-Guerfali DorraMokdad-Gargouri Raja<p>Abstract</p> <p>Backgroud</p> <p>EBV-associated Gastric Carcinoma (EBVaGC) has a distinct clinical features and its prevalence is variable worldwide.</p> <p>Results</p> <p>To determine the prevalence of EBVaGC in Tunisia, EBV-encoded small RNA (EBER) expression was assessed in 81 gastric carcinoma (GC) specimens. The nuclear EBER expression was detected in 12 out of 81 GC cases (14.81%) and concordance between the score range of EBER staining and the number of EBV DNA copies as estimate by QPCR is observed. On the other hand, we found that EBVaGC strongly correlated with age at diagnosis, and weakly with tumor differentiation and venous invasion.</p> <p>Furthermore, the EBVaGC specimens were subjected to determine the EBV DNA polymorphisms. Our results show a unique genetic profile of the EBV strains regarding the A and D types, the F prototype, the retention of <it>Xho</it>I restriction site and the 30 bp del-LMP1 variant. <b><it>According to our previous studies on nasopharyngeal carcinoma (NPC), we suggested that EBV strains associated to GC and NPC shared some similarities in Tunisian patients</it>.</b></p> <p>Conclusion</p> <p>The prevalence of EBVaGC is of 14.81% in the southern Tunisia and that common EBV strain are associated with both NPC and GC which are likely to differ from Asian strains. Our findings support therefore a certain geographical distribution of EBV strains which is not restricted to EBV-associated malignancies.</p>http://www.virologyj.com/content/8/1/500Gastric carcinomaEBVEBERpolymorphisms |
| spellingShingle | Gargouri Ali Sellami-Boudawara Tahia Khabir Abdelmajid Miladi-Abdennadher Imen Ayadi Wajdi BenAyed-Guerfali Dorra Mokdad-Gargouri Raja Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia Virology Journal Gastric carcinoma EBV EBER polymorphisms |
| title | Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia |
| title_full | Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia |
| title_fullStr | Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia |
| title_full_unstemmed | Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia |
| title_short | Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia |
| title_sort | characteristics of epstein barr virus variants associated with gastric carcinoma in southern tunisia |
| topic | Gastric carcinoma EBV EBER polymorphisms |
| url | http://www.virologyj.com/content/8/1/500 |
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