Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient
Over the last decade, a growing interest in the improvement of radiation therapies has led to the development of gold-based nanomaterials as radiosensitizer. Although the radiosensitization effect was initially attributed to a dose enhancement mechanism, an increasing number of studies challenge thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/8/2021 |
| _version_ | 1797561537598062592 |
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| author | Sébastien Penninckx Anne-Catherine Heuskin Carine Michiels Stéphane Lucas |
| author_facet | Sébastien Penninckx Anne-Catherine Heuskin Carine Michiels Stéphane Lucas |
| author_sort | Sébastien Penninckx |
| collection | DOAJ |
| description | Over the last decade, a growing interest in the improvement of radiation therapies has led to the development of gold-based nanomaterials as radiosensitizer. Although the radiosensitization effect was initially attributed to a dose enhancement mechanism, an increasing number of studies challenge this mechanistic hypothesis and evidence the importance of chemical and biological contributions. Despite extensive experimental validation, the debate regarding the mechanism(s) of gold nanoparticle radiosensitization is limiting its clinical translation. This article reviews the current state of knowledge by addressing how gold nanoparticles exert their radiosensitizing effects from a transdisciplinary perspective. We also discuss the current and future challenges to go towards a successful clinical translation of this promising therapeutic approach. |
| first_indexed | 2024-03-10T18:15:21Z |
| format | Article |
| id | doaj.art-c0b0c4e203e3433daea721dd09d8ba2b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:15:21Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c0b0c4e203e3433daea721dd09d8ba2b2023-11-20T07:44:59ZengMDPI AGCancers2072-66942020-07-01128202110.3390/cancers12082021Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to PatientSébastien Penninckx0Anne-Catherine Heuskin1Carine Michiels2Stéphane Lucas3Research Center for the Physics of Matter and Radiation (PMR-LARN), Namur Research Institute For Life Sciences (NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, BelgiumResearch Center for the Physics of Matter and Radiation (PMR-LARN), Namur Research Institute For Life Sciences (NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, BelgiumUnité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute For Life Sciences (NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, BelgiumResearch Center for the Physics of Matter and Radiation (PMR-LARN), Namur Research Institute For Life Sciences (NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, BelgiumOver the last decade, a growing interest in the improvement of radiation therapies has led to the development of gold-based nanomaterials as radiosensitizer. Although the radiosensitization effect was initially attributed to a dose enhancement mechanism, an increasing number of studies challenge this mechanistic hypothesis and evidence the importance of chemical and biological contributions. Despite extensive experimental validation, the debate regarding the mechanism(s) of gold nanoparticle radiosensitization is limiting its clinical translation. This article reviews the current state of knowledge by addressing how gold nanoparticles exert their radiosensitizing effects from a transdisciplinary perspective. We also discuss the current and future challenges to go towards a successful clinical translation of this promising therapeutic approach.https://www.mdpi.com/2072-6694/12/8/2021gold nanoparticleradiosensitizerprotontherapymechanismoxidative stressclinical translation |
| spellingShingle | Sébastien Penninckx Anne-Catherine Heuskin Carine Michiels Stéphane Lucas Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient Cancers gold nanoparticle radiosensitizer protontherapy mechanism oxidative stress clinical translation |
| title | Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient |
| title_full | Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient |
| title_fullStr | Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient |
| title_full_unstemmed | Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient |
| title_short | Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient |
| title_sort | gold nanoparticles as a potent radiosensitizer a transdisciplinary approach from physics to patient |
| topic | gold nanoparticle radiosensitizer protontherapy mechanism oxidative stress clinical translation |
| url | https://www.mdpi.com/2072-6694/12/8/2021 |
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