Advances in Treatment Models of Advanced Gastric Cancer

The prognosis of advanced gastric cancer (AGC) is extremely poor, and the therapeutic effect of traditional palliative chemotherapy is far from satisfactory. To overcome this bottleneck, palliative surgery resection, perioperative chemotherapy combined with surgical resection, hyperthermic intraperi...

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Main Authors: Tao Li, Yufang He, Qinglei Zhong, Jiang Yu, Xinhua Chen
Format: Article
Language:English
Published: SAGE Publishing 2022-09-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/15330338221090353
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author Tao Li
Yufang He
Qinglei Zhong
Jiang Yu
Xinhua Chen
author_facet Tao Li
Yufang He
Qinglei Zhong
Jiang Yu
Xinhua Chen
author_sort Tao Li
collection DOAJ
description The prognosis of advanced gastric cancer (AGC) is extremely poor, and the therapeutic effect of traditional palliative chemotherapy is far from satisfactory. To overcome this bottleneck, palliative surgery resection, perioperative chemotherapy combined with surgical resection, hyperthermic intraperitoneal chemotherapy (HIPEC), pressurized intraperitoneal aerosol chemotherapy (PIPAC), radiation therapy, molecular-targeted therapy have been explored in AGC. Although considerable progress has been achieved, there is still no overwhelming therapeutic method. Due to the high heterogeneity of AGC, it is particularly vital to reshaped the paradigm of gastric cancer therapy according to the characteristics of clinical classifications and molecular subtypes.
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spelling doaj.art-c0b1a7e786a04c05a4d96ace680410402022-12-22T01:52:03ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-09-012110.1177/15330338221090353Advances in Treatment Models of Advanced Gastric CancerTao Li0Yufang He1Qinglei Zhong2Jiang Yu3Xinhua Chen4 Department of General Surgery, , , Guangzhou, China The First Clinical Medical School, , Guangzhou, Guangdong, China The First Clinical Medical School, , Guangzhou, Guangdong, China Department of General Surgery, , , Guangzhou, China Department of General Surgery, , , Guangzhou, ChinaThe prognosis of advanced gastric cancer (AGC) is extremely poor, and the therapeutic effect of traditional palliative chemotherapy is far from satisfactory. To overcome this bottleneck, palliative surgery resection, perioperative chemotherapy combined with surgical resection, hyperthermic intraperitoneal chemotherapy (HIPEC), pressurized intraperitoneal aerosol chemotherapy (PIPAC), radiation therapy, molecular-targeted therapy have been explored in AGC. Although considerable progress has been achieved, there is still no overwhelming therapeutic method. Due to the high heterogeneity of AGC, it is particularly vital to reshaped the paradigm of gastric cancer therapy according to the characteristics of clinical classifications and molecular subtypes.https://doi.org/10.1177/15330338221090353
spellingShingle Tao Li
Yufang He
Qinglei Zhong
Jiang Yu
Xinhua Chen
Advances in Treatment Models of Advanced Gastric Cancer
Technology in Cancer Research & Treatment
title Advances in Treatment Models of Advanced Gastric Cancer
title_full Advances in Treatment Models of Advanced Gastric Cancer
title_fullStr Advances in Treatment Models of Advanced Gastric Cancer
title_full_unstemmed Advances in Treatment Models of Advanced Gastric Cancer
title_short Advances in Treatment Models of Advanced Gastric Cancer
title_sort advances in treatment models of advanced gastric cancer
url https://doi.org/10.1177/15330338221090353
work_keys_str_mv AT taoli advancesintreatmentmodelsofadvancedgastriccancer
AT yufanghe advancesintreatmentmodelsofadvancedgastriccancer
AT qingleizhong advancesintreatmentmodelsofadvancedgastriccancer
AT jiangyu advancesintreatmentmodelsofadvancedgastriccancer
AT xinhuachen advancesintreatmentmodelsofadvancedgastriccancer