Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants
Basic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00757/full |
| _version_ | 1818483625747808256 |
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| author | Subhasis eSamanta Jitendra Kumar Thakur |
| author_facet | Subhasis eSamanta Jitendra Kumar Thakur |
| author_sort | Subhasis eSamanta |
| collection | DOAJ |
| description | Basic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways before channelling the transcription instructions to the RNA polymerase II machinery. Like yeast and metazoans, plants do possess the Mediator complex across the kingdom, and its isolation and subunit analyses have been reported from the model plant, Arabidopsis. Genetic and molecular analyses have unravelled important regulatory roles of Mediator subunits at every stage of plant life cycle starting from flowering to embryo and organ development, to even size determination. It also contributes immensely to the survival of plants against different environmental vagaries by the timely activation of its resistance mechanisms. Here, we have provided an overview of plant Mediator complex starting from its discovery to regulation of stoichiometry of its subunits. We have also reviewed involvement of different Mediator subunits in different processes and pathways including defense response pathways evoked by diverse biotic cues. Wherever possible, attempts have been made to provide mechanistic insight of Mediator’s involvement in these processes. |
| first_indexed | 2024-12-10T15:44:22Z |
| format | Article |
| id | doaj.art-c0b1c381b967417b976733e16802f207 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-10T15:44:22Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-c0b1c381b967417b976733e16802f2072022-12-22T01:43:00ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2015-09-01610.3389/fpls.2015.00757158580Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plantsSubhasis eSamanta0Jitendra Kumar Thakur1national institute of plant genome researchnational institute of plant genome researchBasic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways before channelling the transcription instructions to the RNA polymerase II machinery. Like yeast and metazoans, plants do possess the Mediator complex across the kingdom, and its isolation and subunit analyses have been reported from the model plant, Arabidopsis. Genetic and molecular analyses have unravelled important regulatory roles of Mediator subunits at every stage of plant life cycle starting from flowering to embryo and organ development, to even size determination. It also contributes immensely to the survival of plants against different environmental vagaries by the timely activation of its resistance mechanisms. Here, we have provided an overview of plant Mediator complex starting from its discovery to regulation of stoichiometry of its subunits. We have also reviewed involvement of different Mediator subunits in different processes and pathways including defense response pathways evoked by diverse biotic cues. Wherever possible, attempts have been made to provide mechanistic insight of Mediator’s involvement in these processes.http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00757/fullArabidopsisMediator ComplexRNA Polymerase IIdevelopmentricetranscription |
| spellingShingle | Subhasis eSamanta Jitendra Kumar Thakur Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants Frontiers in Plant Science Arabidopsis Mediator Complex RNA Polymerase II development rice transcription |
| title | Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants |
| title_full | Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants |
| title_fullStr | Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants |
| title_full_unstemmed | Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants |
| title_short | Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants |
| title_sort | importance of mediator complex in the regulation and integration of diverse signaling pathways in plants |
| topic | Arabidopsis Mediator Complex RNA Polymerase II development rice transcription |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00757/full |
| work_keys_str_mv | AT subhasisesamanta importanceofmediatorcomplexintheregulationandintegrationofdiversesignalingpathwaysinplants AT jitendrakumarthakur importanceofmediatorcomplexintheregulationandintegrationofdiversesignalingpathwaysinplants |