Somatic mutation and clonal expansions in human tissues
Editorial summary Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for o...
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Genome Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s13073-019-0648-4 |
| _version_ | 1818498354563252224 |
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| author | Inigo Martincorena |
| author_facet | Inigo Martincorena |
| author_sort | Inigo Martincorena |
| collection | DOAJ |
| description | Editorial summary Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases. |
| first_indexed | 2024-12-10T18:57:42Z |
| format | Article |
| id | doaj.art-c0b3ebe09a68443fade267efdb94a62f |
| institution | Directory Open Access Journal |
| issn | 1756-994X |
| language | English |
| last_indexed | 2024-12-10T18:57:42Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Medicine |
| spelling | doaj.art-c0b3ebe09a68443fade267efdb94a62f2022-12-22T01:37:06ZengBMCGenome Medicine1756-994X2019-05-011111310.1186/s13073-019-0648-4Somatic mutation and clonal expansions in human tissuesInigo Martincorena0Wellcome Sanger InstituteEditorial summary Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.http://link.springer.com/article/10.1186/s13073-019-0648-4 |
| spellingShingle | Inigo Martincorena Somatic mutation and clonal expansions in human tissues Genome Medicine |
| title | Somatic mutation and clonal expansions in human tissues |
| title_full | Somatic mutation and clonal expansions in human tissues |
| title_fullStr | Somatic mutation and clonal expansions in human tissues |
| title_full_unstemmed | Somatic mutation and clonal expansions in human tissues |
| title_short | Somatic mutation and clonal expansions in human tissues |
| title_sort | somatic mutation and clonal expansions in human tissues |
| url | http://link.springer.com/article/10.1186/s13073-019-0648-4 |
| work_keys_str_mv | AT inigomartincorena somaticmutationandclonalexpansionsinhumantissues |