An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells
Cell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs), with their unique characteristics of indefi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1323 |
| _version_ | 1797515313277829120 |
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| author | Li-Jie Hsu Chao-Lin Liu Ming-Ling Kuo Chia-Ning Shen Chia-Rui Shen |
| author_facet | Li-Jie Hsu Chao-Lin Liu Ming-Ling Kuo Chia-Ning Shen Chia-Rui Shen |
| author_sort | Li-Jie Hsu |
| collection | DOAJ |
| description | Cell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs), with their unique characteristics of indefinite expansion in cultures and genetic modifications, represent an ideal cell source for differentiation into specialized cell types. Cell therapy has recently become one of the most promising therapeutic approaches for cancers, and different immune cell types are selected as therapeutic platforms. Natural killer (NK) cells are shown to be effective tumor cell killers and do not cause graft-vs-host disease (GVHD), making them excellent candidates for, and facilitating the development of, “off-the-shelf” cell therapies. In this review, we summarize the progress in the past decade in the advent of iPSC technology and review recent developments in gene-modified iPSC-NK cells as readily available “off-the-shelf” cellular therapies. |
| first_indexed | 2024-03-10T06:43:44Z |
| format | Article |
| id | doaj.art-c0b3ff46e40f408fbd919b5c71bac590 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:43:44Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c0b3ff46e40f408fbd919b5c71bac5902023-11-22T17:30:04ZengMDPI AGBiomedicines2227-90592021-09-01910132310.3390/biomedicines9101323An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer CellsLi-Jie Hsu0Chao-Lin Liu1Ming-Ling Kuo2Chia-Ning Shen3Chia-Rui Shen4Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Chemical Engineering, Ming Chi University of Technology, New Taipei 243, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGenomics Research Center, Academia Sinica, Taipei 115, TaiwanDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanCell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs), with their unique characteristics of indefinite expansion in cultures and genetic modifications, represent an ideal cell source for differentiation into specialized cell types. Cell therapy has recently become one of the most promising therapeutic approaches for cancers, and different immune cell types are selected as therapeutic platforms. Natural killer (NK) cells are shown to be effective tumor cell killers and do not cause graft-vs-host disease (GVHD), making them excellent candidates for, and facilitating the development of, “off-the-shelf” cell therapies. In this review, we summarize the progress in the past decade in the advent of iPSC technology and review recent developments in gene-modified iPSC-NK cells as readily available “off-the-shelf” cellular therapies.https://www.mdpi.com/2227-9059/9/10/1323induced pluripotent stem cells (iPSCs)natural killer cells (NK cells)cell therapy |
| spellingShingle | Li-Jie Hsu Chao-Lin Liu Ming-Ling Kuo Chia-Ning Shen Chia-Rui Shen An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells Biomedicines induced pluripotent stem cells (iPSCs) natural killer cells (NK cells) cell therapy |
| title | An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells |
| title_full | An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells |
| title_fullStr | An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells |
| title_full_unstemmed | An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells |
| title_short | An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells |
| title_sort | alternative cell therapy for cancers induced pluripotent stem cell ipsc derived natural killer cells |
| topic | induced pluripotent stem cells (iPSCs) natural killer cells (NK cells) cell therapy |
| url | https://www.mdpi.com/2227-9059/9/10/1323 |
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