The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebros...
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MDPI AG
2021-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/11/1615 |
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| author | Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric |
| author_facet | Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric |
| author_sort | Julia Masomi-Bornwasser |
| collection | DOAJ |
| description | Spontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebrospinal fluid (CSF) on clinical outcomes in patients with ICH. A total of 19 ICH (volume > 30 cc) patients and 29 control patients were included. From day one until seven, blood and CSF samples were obtained, and ICH volume was calculated. OS markers, like malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-sulfhydryl (GSH), and the total antioxidant status (TAS) were measured. Clinical data on treatment and outcome were determined. Patients with mRS ≤ 4 showed significantly elevated SOD and GSH-Px levels in plasma compared to patients with poor CO (<i>p</i> = 0.004; <i>p</i> = 0.002). Initial increased TAS in plasma and increased MDA in CSF were linked to an unfavorable outcome after six months (<i>p</i> = 0.06, r = 0.45; <i>p</i> = 0.05, r = 0.44). A higher ICH volume was associated with a worse outcome at week six (<i>p</i> = 0.04, r = 0.47). OS plays a significant role in SBI. Larger ICHs, elevated MDA in CSF, and TAS in plasma were associated with a detrimental outcome, whereas higher plasma-SOD and -GSH-Px were associated with a favorable outcome. |
| first_indexed | 2024-03-10T05:40:36Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T05:40:36Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c0b54e7433884d33a91574c6ed48a2f82023-11-22T22:33:47ZengMDPI AGBiomolecules2218-273X2021-11-011111161510.3390/biom11111615The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral HemorrhageJulia Masomi-Bornwasser0Elena Kurz1Christina Frenz2Jan Schmitt3Dominik M. A. Wesp4Jochem König5Johannes Lotz6Florian Ringel7Thomas Kerz8Harald Krenzlin9Naureen Keric10Department of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyInstitute of Clinical and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanySpontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebrospinal fluid (CSF) on clinical outcomes in patients with ICH. A total of 19 ICH (volume > 30 cc) patients and 29 control patients were included. From day one until seven, blood and CSF samples were obtained, and ICH volume was calculated. OS markers, like malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-sulfhydryl (GSH), and the total antioxidant status (TAS) were measured. Clinical data on treatment and outcome were determined. Patients with mRS ≤ 4 showed significantly elevated SOD and GSH-Px levels in plasma compared to patients with poor CO (<i>p</i> = 0.004; <i>p</i> = 0.002). Initial increased TAS in plasma and increased MDA in CSF were linked to an unfavorable outcome after six months (<i>p</i> = 0.06, r = 0.45; <i>p</i> = 0.05, r = 0.44). A higher ICH volume was associated with a worse outcome at week six (<i>p</i> = 0.04, r = 0.47). OS plays a significant role in SBI. Larger ICHs, elevated MDA in CSF, and TAS in plasma were associated with a detrimental outcome, whereas higher plasma-SOD and -GSH-Px were associated with a favorable outcome.https://www.mdpi.com/2218-273X/11/11/1615oxidative stressintracerebral hemorrhageneurological outcomeoxidative stress markerscerebrospinal fluid |
| spellingShingle | Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage Biomolecules oxidative stress intracerebral hemorrhage neurological outcome oxidative stress markers cerebrospinal fluid |
| title | The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_full | The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_fullStr | The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_full_unstemmed | The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_short | The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_sort | influence of oxidative stress on neurological outcomes in spontaneous intracerebral hemorrhage |
| topic | oxidative stress intracerebral hemorrhage neurological outcome oxidative stress markers cerebrospinal fluid |
| url | https://www.mdpi.com/2218-273X/11/11/1615 |
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