Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia
Abstract Neuroinflammation contributes to the pathophysiology of various mental illnesses including schizophrenia. We investigated peripheral inflammatory cytokines as a biomarker for predicting symptomatic remission in patients with first-episode schizophrenia. The study included 224 patients aged...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-023-00398-1 |
| _version_ | 1797558971280654336 |
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| author | Honey Kim Seon-Hwa Baek Ju-Wan Kim Seunghyong Ryu Ju-Yeon Lee Jae-Min Kim Young-Chul Chung Sung-Wan Kim |
| author_facet | Honey Kim Seon-Hwa Baek Ju-Wan Kim Seunghyong Ryu Ju-Yeon Lee Jae-Min Kim Young-Chul Chung Sung-Wan Kim |
| author_sort | Honey Kim |
| collection | DOAJ |
| description | Abstract Neuroinflammation contributes to the pathophysiology of various mental illnesses including schizophrenia. We investigated peripheral inflammatory cytokines as a biomarker for predicting symptomatic remission in patients with first-episode schizophrenia. The study included 224 patients aged 15–60 years who fulfilled the criteria for schizophrenia spectrum disorder with a treatment duration ≤6 months. Serum levels of tumor necrosis factor (TNF) -α, interferon-γ, interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, and IL-12 were measured. Psychotic symptoms, depressive symptoms, and general functioning were assessed using the Positive and Negative Syndrome Scale, Beck Depression Inventory (BDI), Calgary Depression Scale for Schizophrenia, and Personal and Social Performance scale, respectively. Duration of untreated psychosis (DUP) was also recorded. We investigated the factors associated with remission for each sex in logistic regression analysis. In total, 174 patients achieved remission at the 6-month follow-up (females, 83.5%; males, 70.9%). Remission was associated with older age and lower BDI scores in male patients and with lower TNF-α levels and shorter DUP in female patients. Our findings suggest that peripheral inflammatory cytokines may impede early symptomatic remission in female patients with schizophrenia. In addition, depressive symptoms in males and long DUP in females may be poor prognostic factors for early remission in patients with first-episode psychosis. |
| first_indexed | 2024-03-10T17:38:57Z |
| format | Article |
| id | doaj.art-c0b6d0e5be194f71ab2f83ff5dd2d641 |
| institution | Directory Open Access Journal |
| issn | 2754-6993 |
| language | English |
| last_indexed | 2024-03-10T17:38:57Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj.art-c0b6d0e5be194f71ab2f83ff5dd2d6412023-11-20T09:46:04ZengNature PortfolioSchizophrenia2754-69932023-10-01911710.1038/s41537-023-00398-1Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophreniaHoney Kim0Seon-Hwa Baek1Ju-Wan Kim2Seunghyong Ryu3Ju-Yeon Lee4Jae-Min Kim5Young-Chul Chung6Sung-Wan Kim7Department of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry, Chonbuk National University Medical SchoolDepartment of Psychiatry, Chonnam National University Medical SchoolAbstract Neuroinflammation contributes to the pathophysiology of various mental illnesses including schizophrenia. We investigated peripheral inflammatory cytokines as a biomarker for predicting symptomatic remission in patients with first-episode schizophrenia. The study included 224 patients aged 15–60 years who fulfilled the criteria for schizophrenia spectrum disorder with a treatment duration ≤6 months. Serum levels of tumor necrosis factor (TNF) -α, interferon-γ, interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, and IL-12 were measured. Psychotic symptoms, depressive symptoms, and general functioning were assessed using the Positive and Negative Syndrome Scale, Beck Depression Inventory (BDI), Calgary Depression Scale for Schizophrenia, and Personal and Social Performance scale, respectively. Duration of untreated psychosis (DUP) was also recorded. We investigated the factors associated with remission for each sex in logistic regression analysis. In total, 174 patients achieved remission at the 6-month follow-up (females, 83.5%; males, 70.9%). Remission was associated with older age and lower BDI scores in male patients and with lower TNF-α levels and shorter DUP in female patients. Our findings suggest that peripheral inflammatory cytokines may impede early symptomatic remission in female patients with schizophrenia. In addition, depressive symptoms in males and long DUP in females may be poor prognostic factors for early remission in patients with first-episode psychosis.https://doi.org/10.1038/s41537-023-00398-1 |
| spellingShingle | Honey Kim Seon-Hwa Baek Ju-Wan Kim Seunghyong Ryu Ju-Yeon Lee Jae-Min Kim Young-Chul Chung Sung-Wan Kim Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia Schizophrenia |
| title | Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia |
| title_full | Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia |
| title_fullStr | Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia |
| title_full_unstemmed | Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia |
| title_short | Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia |
| title_sort | inflammatory markers of symptomatic remission at 6 months in patients with first episode schizophrenia |
| url | https://doi.org/10.1038/s41537-023-00398-1 |
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