Latent effects of Hsp90 mutants revealed at reduced expression levels.
In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of es...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-06-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3694843?pdf=render |