Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased r...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2012-06-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5512 |
| _version_ | 1797255304570732544 |
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| author | Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov |
| author_facet | Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov |
| author_sort | Andrey Evgen'evich Kratnov |
| collection | DOAJ |
| description | 77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress. |
| first_indexed | 2024-03-08T15:21:41Z |
| format | Article |
| id | doaj.art-c0b703a51cd4415e91d10fab7164fd96 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:43Z |
| publishDate | 2012-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-c0b703a51cd4415e91d10fab7164fd962024-03-20T11:47:57ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-06-01152131610.14341/2072-0351-55125470Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndromeAndrey Evgen'evich Kratnov0Elena Nikolaevna Lopatnikova1Alexander Andreevich Kratnov2Yaroslavl State Medical Academy, YaroslavlYaroslavl State Medical Academy, YaroslavlYaroslavl State Medical Academy, Yaroslavl77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress.https://www.dia-endojournals.ru/jour/article/view/5512metabolic syndromediabetes mellitus type 2neutrophilsreactive oxygen speciesantioxidants |
| spellingShingle | Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome Сахарный диабет metabolic syndrome diabetes mellitus type 2 neutrophils reactive oxygen species antioxidants |
| title | Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| title_full | Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| title_fullStr | Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| title_full_unstemmed | Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| title_short | Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| title_sort | intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome |
| topic | metabolic syndrome diabetes mellitus type 2 neutrophils reactive oxygen species antioxidants |
| url | https://www.dia-endojournals.ru/jour/article/view/5512 |
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