Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice
Although the importance of LDL cholesterol lowering is widely recognized, the impact of the cholesterol-lowering pattern on the atherosclerosis remains unclear. Here, we used cholestyramine in apolipoprotein E deficient mice in two different regimens to induce a see-saw shaped or a sustained cholest...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861316301499 |
| _version_ | 1818692114456772608 |
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| author | Yusuke Masuda Shinji Yamaguchi Tomohiro Nishizawa |
| author_facet | Yusuke Masuda Shinji Yamaguchi Tomohiro Nishizawa |
| author_sort | Yusuke Masuda |
| collection | DOAJ |
| description | Although the importance of LDL cholesterol lowering is widely recognized, the impact of the cholesterol-lowering pattern on the atherosclerosis remains unclear. Here, we used cholestyramine in apolipoprotein E deficient mice in two different regimens to induce a see-saw shaped or a sustained cholesterol reduction, with the trough of cholesterol comparable. After 12 weeks-treatment, a sustained cholesterol reduction exhibited a smaller atherosclerotic area. Moreover, we observed a correlation between the area under the curve of plasma cholesterol and the atherosclerotic area. These results suggest that the sustained cholesterol reduction is beneficial for preventing the progression of atherosclerosis in cholesterol lowering therapy. |
| first_indexed | 2024-12-17T12:52:38Z |
| format | Article |
| id | doaj.art-c0bb104921bf47fb9c9eaaea4cfcf28e |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-17T12:52:38Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-c0bb104921bf47fb9c9eaaea4cfcf28e2022-12-21T21:47:34ZengElsevierJournal of Pharmacological Sciences1347-86132016-12-01132427127410.1016/j.jphs.2016.11.001Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient miceYusuke Masuda0Shinji Yamaguchi1Tomohiro Nishizawa2End-Organ Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanVenture Science Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanEnd-Organ Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanAlthough the importance of LDL cholesterol lowering is widely recognized, the impact of the cholesterol-lowering pattern on the atherosclerosis remains unclear. Here, we used cholestyramine in apolipoprotein E deficient mice in two different regimens to induce a see-saw shaped or a sustained cholesterol reduction, with the trough of cholesterol comparable. After 12 weeks-treatment, a sustained cholesterol reduction exhibited a smaller atherosclerotic area. Moreover, we observed a correlation between the area under the curve of plasma cholesterol and the atherosclerotic area. These results suggest that the sustained cholesterol reduction is beneficial for preventing the progression of atherosclerosis in cholesterol lowering therapy.http://www.sciencedirect.com/science/article/pii/S1347861316301499AtherosclerosisCholesterol-lowering pattern;PCSK9 |
| spellingShingle | Yusuke Masuda Shinji Yamaguchi Tomohiro Nishizawa Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice Journal of Pharmacological Sciences Atherosclerosis Cholesterol-lowering pattern; PCSK9 |
| title | Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice |
| title_full | Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice |
| title_fullStr | Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice |
| title_full_unstemmed | Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice |
| title_short | Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice |
| title_sort | cholesterol lowering pattern affects the progression of atherosclerosis in apolipoprotein e deficient mice |
| topic | Atherosclerosis Cholesterol-lowering pattern; PCSK9 |
| url | http://www.sciencedirect.com/science/article/pii/S1347861316301499 |
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