A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson’s disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a role in the trafficking of synaptic vesicles (SVs) during neurotransmit...

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Detalhes bibliográficos
Principais autores:	Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Formato:	Artigo
Idioma:	English
Publicado em:	Frontiers Media S.A. 2020-01-01
coleção:	Frontiers in Neuroscience
Assuntos:	α-synuclein synaptic vesicles membrane interaction cholesterol nuclear magnetic resonance
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnins.2020.00018/full

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