A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson’s disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a role in the trafficking of synaptic vesicles (SVs) during neurotransmit...

书目详细资料
Main Authors:	Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
格式:	文件
语言:	English
出版:	Frontiers Media S.A. 2020-01-01
丛编:	Frontiers in Neuroscience
主题:	α-synuclein synaptic vesicles membrane interaction cholesterol nuclear magnetic resonance
在线阅读:	https://www.frontiersin.org/article/10.3389/fnins.2020.00018/full

相似书籍

α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
由: Lennart Brodin, et al.
出版: (2022-05-01)

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
由: Chuchu Wang, et al.
出版: (2024-12-01)

Tyrosine Nitroxidation Does Not Affect the Ability of α-Synuclein to Bind Anionic Micelles, but It Diminishes Its Ability to Bind and Assemble Synaptic-like Vesicles
由: Ana Belén Uceda, et al.
出版: (2023-06-01)

The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking
由: Tapojyoti Das, et al.
出版: (2022-12-01)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
由: Jiajie Diao, et al.
出版: (2013-04-01)

Synapsin E-domain is essential for α-synuclein function
由: Alexandra Stavsky, et al.
出版: (2024-05-01)

Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells
由: Can Wang, et al.
出版: (2018-12-01)

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease
由: Chen-Chih Chung, et al.
出版: (2021-05-01)

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
由: Mingzhu Huang, et al.
出版: (2019-01-01)

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
由: Pan Wang, et al.
出版: (2023-08-01)

Dysfunction of Synaptic Vesicle Endocytosis in Parkinson’s Disease
由: Li Zou, et al.
出版: (2021-05-01)

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
由: Cabeza-Arvelaiz Yofre, et al.
出版: (2011-12-01)

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
由: Eric N. Anderson, et al.
出版: (2020-01-01)

α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization
由: Benjamin Feller, et al.
出版: (2023-04-01)

α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease
由: Kathrine Stokholm, et al.
出版: (2021-12-01)

The Effect of Aggregated Alpha Synuclein on Synaptic and Axonal Proteins in Parkinson’s Disease—A Systematic Review
由: Jennifer Murphy, et al.
出版: (2022-08-01)

Spontaneous Vesicle Recycling in the Synaptic Bouton
由: Sven eTruckenbrodt, et al.
出版: (2014-12-01)

Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts
由: Marco Emanuele, et al.
出版: (2016-05-01)

Plasticity of Membrane Binding by the Central Region of α-Synuclein
由: Carlos Navarro-Paya, et al.
出版: (2022-06-01)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
由: Antonio Heras-Garvin, et al.
出版: (2020-09-01)

Metal interactions of α-synuclein probed by NMR amide-proton exchange
由: Mario Gonzalez-Garcia, et al.
出版: (2023-05-01)

Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease
由: Chu Hua Chang, et al.
出版: (2024-09-01)

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
由: Michiyo Iba, et al.
出版: (2020-03-01)

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway
由: Atikam Qurban, et al.
出版: (2025-01-01)

Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough
由: Upasana Ganguly, et al.
出版: (2021-07-01)

α-Synuclein-induced deformation of small unilamellar vesicles
由: Katarzyna Makasewicz, et al.
出版: (2022-01-01)

β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease
由: Pablo Mohaupt, et al.
出版: (2022-11-01)

Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol
由: Sho Aoki, et al.
出版: (2022-01-01)

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes
由: Carlos Navarro-Paya, et al.
出版: (2020-06-01)

α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties
由: Lindsey G. Soll, et al.
出版: (2020-05-01)

Characterization of α-synuclein oligomers formed in the presence of lipid vesicles
由: Anvesh K.R. Dasari, et al.
出版: (2024-07-01)

NMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies
由: Maria Italia, et al.
出版: (2022-06-01)

Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein
由: Yoshitsugu Nakamura, et al.
出版: (2024-12-01)

Potential for Therapeutic-Loaded Exosomes to Ameliorate the Pathogenic Effects of α-Synuclein in Parkinson’s Disease
由: David J. Rademacher
出版: (2023-04-01)

The Synucleins and the Astrocyte
由: Abigail J. Myers, et al.
出版: (2023-01-01)

The Effects of Lipids on α-Synuclein Aggregation In Vitro
由: Jennifer Ramirez, et al.
出版: (2023-10-01)

Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain
由: Lynne Chantranupong, et al.
出版: (2020-10-01)

Conditional Synaptic Vesicle Markers for Drosophila
由: Jessica L. Williams, et al.
出版: (2019-03-01)

Neuroprotective function of Omi to α-synuclein-induced neurotoxicity
由: Hea-Jong Chung, et al.
出版: (2020-03-01)

Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment
由: Huisheng Liu, et al.
出版: (2014-02-01)