T lymphocytes from chronic HCV-infected patients are primed for activation-induced apoptosis and express unique pro-apoptotic gene signature.

T lymphocytes from chronic HCV-infected patients are primed for activation-induced apoptosis and express unique pro-apoptotic gene signature.

Although extensive studies have demonstrated the functional impairment of antigen-specific CD4(+) and CD8(+) T-cells during chronic hepatitis C virus (HCV) infection, the functional status of global CD4(+) and CD8(+) T-cells remains unclear. In this report, we recruited 42 long-term (~20 years) trea...

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Bibliographic Details
Main Authors: Bin-Bin Zhao, Su-Jun Zheng, Lu-Lu Gong, Yu Wang, Cai-Feng Chen, Wen-Jing Jin, Ding Zhang, Xiao-Hui Yuan, Jian Guo, Zhong-Ping Duan, You-Wen He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3794995?pdf=render

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