Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles
Nicotinamide mononucleotide (NMN), which has recently been spotlighted as an anti-aging agent, is a precursor of the coenzyme nicotinamide adenine dinucleotide that plays an important role in intracellular redox reactions. NMN capsules for oral administration currently on the market have a problem i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/9/2031 |
| _version_ | 1797601948371779584 |
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| author | Farzaneh Sabbagh Beom-Soo Kim |
| author_facet | Farzaneh Sabbagh Beom-Soo Kim |
| author_sort | Farzaneh Sabbagh |
| collection | DOAJ |
| description | Nicotinamide mononucleotide (NMN), which has recently been spotlighted as an anti-aging agent, is a precursor of the coenzyme nicotinamide adenine dinucleotide that plays an important role in intracellular redox reactions. NMN capsules for oral administration currently on the market have a problem in that they are almost fully metabolized in the stomach and liver and excreted as nicotinamide. Therefore, there is a need to develop a patient-friendly delivery method that can improve the bioavailability of NMN. For this purpose, various polyvinyl alcohol (PVA)-based microneedle patches were fabricated to develop a transdermal delivery system for NMN. First, the molecular weight effect of PVA on the shape and microstructure of microneedles was studied. After selecting the optimal molecular weight PVA, the swelling of the microneedles and the ex vivo release of NMN were studied. The effect of carboxymethyl cellulose (CMC) and dimethyl sulfoxide on NMN release was also investigated. The highest NMN release of 91.94% in 18 h was obtained using a 9.5 kDa molecular weight PVA microneedle containing NMN and CMC. |
| first_indexed | 2024-03-11T04:09:26Z |
| format | Article |
| id | doaj.art-c0bce50d265a473480bfff2f488c6407 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T04:09:26Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c0bce50d265a473480bfff2f488c64072023-11-17T23:34:14ZengMDPI AGPolymers2073-43602023-04-01159203110.3390/polym15092031Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol MicroneedlesFarzaneh Sabbagh0Beom-Soo Kim1Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Chemical Engineering, Chungbuk National University, Cheongju 28644, Republic of KoreaNicotinamide mononucleotide (NMN), which has recently been spotlighted as an anti-aging agent, is a precursor of the coenzyme nicotinamide adenine dinucleotide that plays an important role in intracellular redox reactions. NMN capsules for oral administration currently on the market have a problem in that they are almost fully metabolized in the stomach and liver and excreted as nicotinamide. Therefore, there is a need to develop a patient-friendly delivery method that can improve the bioavailability of NMN. For this purpose, various polyvinyl alcohol (PVA)-based microneedle patches were fabricated to develop a transdermal delivery system for NMN. First, the molecular weight effect of PVA on the shape and microstructure of microneedles was studied. After selecting the optimal molecular weight PVA, the swelling of the microneedles and the ex vivo release of NMN were studied. The effect of carboxymethyl cellulose (CMC) and dimethyl sulfoxide on NMN release was also investigated. The highest NMN release of 91.94% in 18 h was obtained using a 9.5 kDa molecular weight PVA microneedle containing NMN and CMC.https://www.mdpi.com/2073-4360/15/9/2031nicotinamide mononucleotidetransdermal deliverypatchpolyvinyl alcoholcarboxymethyl cellulose |
| spellingShingle | Farzaneh Sabbagh Beom-Soo Kim Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles Polymers nicotinamide mononucleotide transdermal delivery patch polyvinyl alcohol carboxymethyl cellulose |
| title | Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles |
| title_full | Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles |
| title_fullStr | Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles |
| title_full_unstemmed | Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles |
| title_short | Ex Vivo Transdermal Delivery of Nicotinamide Mononucleotide Using Polyvinyl Alcohol Microneedles |
| title_sort | ex vivo transdermal delivery of nicotinamide mononucleotide using polyvinyl alcohol microneedles |
| topic | nicotinamide mononucleotide transdermal delivery patch polyvinyl alcohol carboxymethyl cellulose |
| url | https://www.mdpi.com/2073-4360/15/9/2031 |
| work_keys_str_mv | AT farzanehsabbagh exvivotransdermaldeliveryofnicotinamidemononucleotideusingpolyvinylalcoholmicroneedles AT beomsookim exvivotransdermaldeliveryofnicotinamidemononucleotideusingpolyvinylalcoholmicroneedles |