Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients
Introduction Some studies reported that vaccines are extremely good at preventing serious illness but that many countries have had difficulty vaccinating their citizens, and even some vaccinated people may still be at risk for serious COVID-19 symptoms due to underlying medical illness or reduced i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823008817/type/journal_article |
| _version_ | 1797616810896392192 |
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| author | L. Spirkoska A. Spasovska Trajkovska Z. Mitik |
| author_facet | L. Spirkoska A. Spasovska Trajkovska Z. Mitik |
| author_sort | L. Spirkoska |
| collection | DOAJ |
| description |
Introduction
Some studies reported that vaccines are extremely good at preventing serious illness but that many countries have had difficulty vaccinating their citizens, and even some vaccinated people may still be at risk for serious COVID-19 symptoms due to underlying medical illness or reduced immunity over time.
Objectives
Some researches reported that drugs known as selective serotonin-reuptake inhibitors (SSRIs) interacts strongly with the sigma-1 receptor, a protein inside cells that helps regulate the body’s inflammatory response. So its believe that this drug most likely is interacting with the sigma-1 receptor to reduce the production of inflammatory molecules in the body, So treatment with this therapy may be highly effective to reducing severe of COVID symptomatology.
Methods
The cross-section study included two groups of patients (N = 30) of different sex ±49,2 age, all were treated in Covid Centre , Skopje. The study was conducted for 6 months all the patients was writing informed consent. The first group consisted of COVID patients who had previously suffered from psychiatric illness and had been treated with antidepressant therapy (SSRi). The second group are the COVID patients who had not been treated with antidepressant before. The severity of COVID 19 symptomatology (based on medical documentation- classification of disease severity) was determined using the Modified Early Warning Score (MEWS scale) . MEWS score 0-2 mild or asymptomatic (stable patients), 3-4 moderately severe (unstable patients), ≥ 5 highly critical(critical patients). The obtained data were processed by descriptive method and Student t-test.
Results
. The results in our study show that the patients who were treated with antidepressants before covid disease showed a lower score on the NEWS scale but there is a not statistically significant results p=0,06 when compare with another examination group
Conclusions
: The results in our study supports considerations about the possible impact of antidepressant therapy on alleviating COVID 19 symptomatology.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:46:41Z |
| format | Article |
| id | doaj.art-c0bdde036e95403ca4fda3c2ffe8f31e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:46:41Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-c0bdde036e95403ca4fda3c2ffe8f31e2023-11-17T05:07:38ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S409S40910.1192/j.eurpsy.2023.881Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patientsL. Spirkoska0A. Spasovska Trajkovska1Z. Mitik2Psychiatry, GOB 8SeptemvriPsihijatriska Bolnica SkopjePsychiatry, PZU Zora Mitik, Skopje, North Macedonia Introduction Some studies reported that vaccines are extremely good at preventing serious illness but that many countries have had difficulty vaccinating their citizens, and even some vaccinated people may still be at risk for serious COVID-19 symptoms due to underlying medical illness or reduced immunity over time. Objectives Some researches reported that drugs known as selective serotonin-reuptake inhibitors (SSRIs) interacts strongly with the sigma-1 receptor, a protein inside cells that helps regulate the body’s inflammatory response. So its believe that this drug most likely is interacting with the sigma-1 receptor to reduce the production of inflammatory molecules in the body, So treatment with this therapy may be highly effective to reducing severe of COVID symptomatology. Methods The cross-section study included two groups of patients (N = 30) of different sex ±49,2 age, all were treated in Covid Centre , Skopje. The study was conducted for 6 months all the patients was writing informed consent. The first group consisted of COVID patients who had previously suffered from psychiatric illness and had been treated with antidepressant therapy (SSRi). The second group are the COVID patients who had not been treated with antidepressant before. The severity of COVID 19 symptomatology (based on medical documentation- classification of disease severity) was determined using the Modified Early Warning Score (MEWS scale) . MEWS score 0-2 mild or asymptomatic (stable patients), 3-4 moderately severe (unstable patients), ≥ 5 highly critical(critical patients). The obtained data were processed by descriptive method and Student t-test. Results . The results in our study show that the patients who were treated with antidepressants before covid disease showed a lower score on the NEWS scale but there is a not statistically significant results p=0,06 when compare with another examination group Conclusions : The results in our study supports considerations about the possible impact of antidepressant therapy on alleviating COVID 19 symptomatology. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823008817/type/journal_article |
| spellingShingle | L. Spirkoska A. Spasovska Trajkovska Z. Mitik Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients European Psychiatry |
| title | Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients |
| title_full | Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients |
| title_fullStr | Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients |
| title_full_unstemmed | Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients |
| title_short | Effect of antidepressant therapy on the severity of COVID 19 symptomatology in the hospitalized patients |
| title_sort | effect of antidepressant therapy on the severity of covid 19 symptomatology in the hospitalized patients |
| url | https://www.cambridge.org/core/product/identifier/S0924933823008817/type/journal_article |
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