Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.
Kidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein 4 (IGFBP-...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4809566?pdf=render |
| _version_ | 1811221764617797632 |
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| author | Tianfu Wu Chun Xie Jie Han Yujin Ye Sandeep Singh Jinchun Zhou Yajuan Li Huihua Ding Quan-zhen Li Xin Zhou Chaim Putterman Ramesh Saxena Chandra Mohan |
| author_facet | Tianfu Wu Chun Xie Jie Han Yujin Ye Sandeep Singh Jinchun Zhou Yajuan Li Huihua Ding Quan-zhen Li Xin Zhou Chaim Putterman Ramesh Saxena Chandra Mohan |
| author_sort | Tianfu Wu |
| collection | DOAJ |
| description | Kidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein 4 (IGFBP-4) was increased in diabetic nephropathy in both animal models and patients. We proceeded to assess if IGFBP4 could be associated with LN. We performed ELISA using the serum of 86 patients with LN. Normal healthy adults (N = 23) and patients with other glomerular diseases (N = 20) served as controls. Compared to the healthy controls or other glomerular disease controls, serum IGFBP-4 levels were significantly higher in the patients with LN. Serum IGFBP-4 did not correlate well with systemic lupus erythematosus disease activity index (SLEDAI), renal SLEDAI or proteinuria, but it did correlate with estimated glomerular filtration rate (R = 0.609, P < 0.0001). Interestingly, in 18 patients with proliferative LN whose blood samples were obtained at the time of renal biopsy, serum IGFBP-4 levels correlated strongly with the chronicity index of renal pathology (R = 0.713, P < 0.001). IGFBP-4 emerges a potential marker of lupus nephritis, reflective of renal pathology chronicity changes. |
| first_indexed | 2024-04-12T08:06:03Z |
| format | Article |
| id | doaj.art-c0c190cef6014f5b9eecf49f0c7ebc57 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T08:06:03Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c0c190cef6014f5b9eecf49f0c7ebc572022-12-22T03:41:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015149110.1371/journal.pone.0151491Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.Tianfu WuChun XieJie HanYujin YeSandeep SinghJinchun ZhouYajuan LiHuihua DingQuan-zhen LiXin ZhouChaim PuttermanRamesh SaxenaChandra MohanKidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein 4 (IGFBP-4) was increased in diabetic nephropathy in both animal models and patients. We proceeded to assess if IGFBP4 could be associated with LN. We performed ELISA using the serum of 86 patients with LN. Normal healthy adults (N = 23) and patients with other glomerular diseases (N = 20) served as controls. Compared to the healthy controls or other glomerular disease controls, serum IGFBP-4 levels were significantly higher in the patients with LN. Serum IGFBP-4 did not correlate well with systemic lupus erythematosus disease activity index (SLEDAI), renal SLEDAI or proteinuria, but it did correlate with estimated glomerular filtration rate (R = 0.609, P < 0.0001). Interestingly, in 18 patients with proliferative LN whose blood samples were obtained at the time of renal biopsy, serum IGFBP-4 levels correlated strongly with the chronicity index of renal pathology (R = 0.713, P < 0.001). IGFBP-4 emerges a potential marker of lupus nephritis, reflective of renal pathology chronicity changes.http://europepmc.org/articles/PMC4809566?pdf=render |
| spellingShingle | Tianfu Wu Chun Xie Jie Han Yujin Ye Sandeep Singh Jinchun Zhou Yajuan Li Huihua Ding Quan-zhen Li Xin Zhou Chaim Putterman Ramesh Saxena Chandra Mohan Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. PLoS ONE |
| title | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. |
| title_full | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. |
| title_fullStr | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. |
| title_full_unstemmed | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. |
| title_short | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. |
| title_sort | insulin like growth factor binding protein 4 as a marker of chronic lupus nephritis |
| url | http://europepmc.org/articles/PMC4809566?pdf=render |
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