Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

Doublecortin (DCX) is a microtubule (MT)-associated protein that regulates MT structure and function during neuronal development and mutations in DCX lead to a spectrum of neurological disorders. The structural properties of MT-bound DCX that explain these disorders are incompletely determined. Here...

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Bibliographic Details
Main Authors: Atefeh Rafiei, Sofía Cruz Tetlalmatzi, Claire H Edrington, Linda Lee, D Alex Crowder, Daniel J Saltzberg, Andrej Sali, Gary Brouhard, David C Schriemer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
Doublecortin
microtubules
neurons
mass spectrometry
integrative modeling
electron microscopy
Online Access:https://elifesciences.org/articles/66975

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