Pancreatic β Cells Inhibit Glucagon Secretion from α Cells: An In Vitro Demonstration of α–β Cell Interaction

Pancreatic β Cells Inhibit Glucagon Secretion from α Cells: An In Vitro Demonstration of α–β Cell Interaction

Interactions between endocrine α and β cells are critical to their secretory function in vivo. The interactions are highly regulated, although yet to be fully understood. In this study, we aim to assess the impact of α and β cell co-culture on hormone secretion. Mouse clonal cell lines α-TC6-1 (α ce...

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Bibliographic Details
Main Authors: Wenqian Gu, Camilla Christine Bundgaard Anker, Christine Bodelund Christiansen, Tilo Moede, Per-Olof Berggren, Kjeld Hermansen, Søren Gregersen, Per Bendix Jeppesen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Nutrients
Subjects:
MIN-6
α-TC6-1
α–β cell interaction
glucagon secretion
insulin secretion
co-culture
Online Access:https://www.mdpi.com/2072-6643/13/7/2281

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