Dynamic and unpredictable changes in mutant allele fractions of BRAF and NRAS during visceral progression of cutaneous malignant melanoma

Dynamic and unpredictable changes in mutant allele fractions of BRAF and NRAS during visceral progression of cutaneous malignant melanoma

Abstract Background Data indicate that primary cutaneous melanomas are characterized by clonal heterogeneity associated with oncogenic drivers. Less data are available on the clonal changes occurring during melanoma progression. We therefore wished to analyse these changes in skin melanomas in commo...

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Bibliographic Details
Main Authors: V. Doma, S. Kárpáti, E. Rásó, T. Barbai, J. Tímár
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Mutant allele fraction
BRAF
Melanoma
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-019-5990-9

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