Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives
Coumarins are oxygen heterocyclic compounds that exist naturally and have a wide range of pharmacological properties, making them ideal as lead compounds for developing more powerful analogs. The modification of 4-methyl, 7-hydroxycoumarin by different reaction steps was done in this study to yield...
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| Format: | Article |
| Language: | English |
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University of Technology, Baghdad
2021-12-01
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| Series: | Journal of Applied Sciences and Nanotechnology |
| Subjects: | |
| Online Access: | https://jasn.uotechnology.edu.iq/article_16509_040196cac844936266aef14c871de367.pdf |
| _version_ | 1819104266716971008 |
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| author | Yasameen Al-Majedy Samar Shakir |
| author_facet | Yasameen Al-Majedy Samar Shakir |
| author_sort | Yasameen Al-Majedy |
| collection | DOAJ |
| description | Coumarins are oxygen heterocyclic compounds that exist naturally and have a wide range of pharmacological properties, making them ideal as lead compounds for developing more powerful analogs. The modification of 4-methyl, 7-hydroxycoumarin by different reaction steps was done in this study to yield target compounds. They were characterized by different spectroscopic techniques (FT-IR and NMR), melting point and a thin layer chromatography. The microbiological activity of these compounds was investigated in a variety of bacterial and fungal species. Since the newly synthesized derivatives contain a variety of functional groups and may be microbiologically active, so the microbiological function of these derivatives in a variety of bacteria and fungi species was examined. In terms of the microorganism growth inhibition, the prepared compounds showed various levels of the activity. Antimicrobial properties have been discovered in newly synthesized derivatives. Density functional theory calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. |
| first_indexed | 2024-12-22T02:03:38Z |
| format | Article |
| id | doaj.art-c0c4e8ae858f429b93a8c7f8d2e5c5a7 |
| institution | Directory Open Access Journal |
| issn | 2788-6867 |
| language | English |
| last_indexed | 2024-12-22T02:03:38Z |
| publishDate | 2021-12-01 |
| publisher | University of Technology, Baghdad |
| record_format | Article |
| series | Journal of Applied Sciences and Nanotechnology |
| spelling | doaj.art-c0c4e8ae858f429b93a8c7f8d2e5c5a72022-12-21T18:42:36ZengUniversity of Technology, BaghdadJournal of Applied Sciences and Nanotechnology2788-68672021-12-0121202710.53293/jasn.2021.4164.107616509Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin DerivativesYasameen Al-Majedy0Samar Shakir1Branch of Chemistry, Department of Applied Sciences, University of Technology – IraqBranch of Chemistry, Department of Applied Sciences, University of Technology – IraqCoumarins are oxygen heterocyclic compounds that exist naturally and have a wide range of pharmacological properties, making them ideal as lead compounds for developing more powerful analogs. The modification of 4-methyl, 7-hydroxycoumarin by different reaction steps was done in this study to yield target compounds. They were characterized by different spectroscopic techniques (FT-IR and NMR), melting point and a thin layer chromatography. The microbiological activity of these compounds was investigated in a variety of bacterial and fungal species. Since the newly synthesized derivatives contain a variety of functional groups and may be microbiologically active, so the microbiological function of these derivatives in a variety of bacteria and fungi species was examined. In terms of the microorganism growth inhibition, the prepared compounds showed various levels of the activity. Antimicrobial properties have been discovered in newly synthesized derivatives. Density functional theory calculations of the synthesized coumarins were performed using molecular structures with optimized geometries.https://jasn.uotechnology.edu.iq/article_16509_040196cac844936266aef14c871de367.pdfthree coumarinhydrazinhydratedft |
| spellingShingle | Yasameen Al-Majedy Samar Shakir Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives Journal of Applied Sciences and Nanotechnology three coumarin hydrazinhydrate dft |
| title | Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives |
| title_full | Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives |
| title_fullStr | Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives |
| title_full_unstemmed | Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives |
| title_short | Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives |
| title_sort | synthesis bio evaluation and quantum chemical studies of some coumarin derivatives |
| topic | three coumarin hydrazinhydrate dft |
| url | https://jasn.uotechnology.edu.iq/article_16509_040196cac844936266aef14c871de367.pdf |
| work_keys_str_mv | AT yasameenalmajedy synthesisbioevaluationandquantumchemicalstudiesofsomecoumarinderivatives AT samarshakir synthesisbioevaluationandquantumchemicalstudiesofsomecoumarinderivatives |