Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation
Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate the mechanical and biological properties of the a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2022.2153823 |
| _version_ | 1797684092939010048 |
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| author | Jacob Ranjbar Ying Yang Alan G.S. Harper |
| author_facet | Jacob Ranjbar Ying Yang Alan G.S. Harper |
| author_sort | Jacob Ranjbar |
| collection | DOAJ |
| description | Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate the mechanical and biological properties of the arterial wall. Current in vitro thrombosis models principally use reductionist approaches to model the complex biochemical and cellular milieu present in the arterial wall, and so researcher have favored the use of in vivo models. The field of vascular tissue engineering has developed a range of techniques for culturing artificial human arteries for use as vascular grafts. These techniques therefore provide a basis for developing more sophisticated 3D replicas of the arterial wall that can be used in in vitro thrombosis models. In this review, we consider how tissue engineering approaches can be used to generate 3D models of the arterial wall that improve upon current in vivo and in vitro approaches. We consider the current benefits and limitations of reported 3D tissue engineered models and consider what additional evidence is required to validate them as alternatives to current in vivo models. |
| first_indexed | 2024-03-12T00:25:31Z |
| format | Article |
| id | doaj.art-c0c54cb0f9a946d293b7c90fd998cb4b |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:31Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-c0c54cb0f9a946d293b7c90fd998cb4b2023-09-15T10:38:11ZengTaylor & Francis GroupPlatelets0953-71041369-16352023-12-0134110.1080/09537104.2022.21538232153823Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formationJacob Ranjbar0Ying Yang1Alan G.S. Harper2Keele UniversityKeele UniversityKeele UniversityThrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate the mechanical and biological properties of the arterial wall. Current in vitro thrombosis models principally use reductionist approaches to model the complex biochemical and cellular milieu present in the arterial wall, and so researcher have favored the use of in vivo models. The field of vascular tissue engineering has developed a range of techniques for culturing artificial human arteries for use as vascular grafts. These techniques therefore provide a basis for developing more sophisticated 3D replicas of the arterial wall that can be used in in vitro thrombosis models. In this review, we consider how tissue engineering approaches can be used to generate 3D models of the arterial wall that improve upon current in vivo and in vitro approaches. We consider the current benefits and limitations of reported 3D tissue engineered models and consider what additional evidence is required to validate them as alternatives to current in vivo models.http://dx.doi.org/10.1080/09537104.2022.21538233rs, in vitro modelsthrombus formation, vascular tissue engineering |
| spellingShingle | Jacob Ranjbar Ying Yang Alan G.S. Harper Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation Platelets 3rs, in vitro models thrombus formation, vascular tissue engineering |
| title | Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| title_full | Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| title_fullStr | Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| title_full_unstemmed | Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| title_short | Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| title_sort | developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation |
| topic | 3rs, in vitro models thrombus formation, vascular tissue engineering |
| url | http://dx.doi.org/10.1080/09537104.2022.2153823 |
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