Hypoxia and Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide and comprises varied grades of intrahepatic lipid accumulation, inflammation, ballooning, and fibrosis; the most severe cases result in cirrhosis and liver failure. There is extensive clinical and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.578001/full |
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| author | Stephania C. Isaza Elvira del Pozo-Maroto Lucía Domínguez-Alcón Liliam Elbouayadi Águeda González-Rodríguez Carmelo García-Monzón |
| author_facet | Stephania C. Isaza Elvira del Pozo-Maroto Lucía Domínguez-Alcón Liliam Elbouayadi Águeda González-Rodríguez Carmelo García-Monzón |
| author_sort | Stephania C. Isaza |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide and comprises varied grades of intrahepatic lipid accumulation, inflammation, ballooning, and fibrosis; the most severe cases result in cirrhosis and liver failure. There is extensive clinical and experimental evidence indicating that chronic intermittent hypoxia, featuring a respiratory disorder of growing prevalence worldwide termed obstructive sleep apnea, could contribute to the progression of NAFLD from simple steatosis, also termed non-alcoholic fatty liver or hepatosteatosis, to non-alcoholic steatohepatitis; however, the molecular mechanisms by which hypoxia might contribute to hepatosteatosis setup and progression still remain to be fully elucidated. In this review, we have prepared an overview about the link between hypoxia and lipid accumulation within the liver, focusing on the impact of hypoxia on the molecular mechanisms underlying hepatosteatosis onset. |
| first_indexed | 2024-12-13T07:00:51Z |
| format | Article |
| id | doaj.art-c0c76a0a5da54d0c9bb4118192058aa2 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T07:00:51Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-c0c76a0a5da54d0c9bb4118192058aa22022-12-21T23:55:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-10-01710.3389/fmed.2020.578001578001Hypoxia and Non-alcoholic Fatty Liver DiseaseStephania C. IsazaElvira del Pozo-MarotoLucía Domínguez-AlcónLiliam ElbouayadiÁgueda González-RodríguezCarmelo García-MonzónNon-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide and comprises varied grades of intrahepatic lipid accumulation, inflammation, ballooning, and fibrosis; the most severe cases result in cirrhosis and liver failure. There is extensive clinical and experimental evidence indicating that chronic intermittent hypoxia, featuring a respiratory disorder of growing prevalence worldwide termed obstructive sleep apnea, could contribute to the progression of NAFLD from simple steatosis, also termed non-alcoholic fatty liver or hepatosteatosis, to non-alcoholic steatohepatitis; however, the molecular mechanisms by which hypoxia might contribute to hepatosteatosis setup and progression still remain to be fully elucidated. In this review, we have prepared an overview about the link between hypoxia and lipid accumulation within the liver, focusing on the impact of hypoxia on the molecular mechanisms underlying hepatosteatosis onset.https://www.frontiersin.org/articles/10.3389/fmed.2020.578001/fullobstructive sleep apneaNAFLDhypoxiahypoxia-inducible factors (HIFs)hepatosteatosis |
| spellingShingle | Stephania C. Isaza Elvira del Pozo-Maroto Lucía Domínguez-Alcón Liliam Elbouayadi Águeda González-Rodríguez Carmelo García-Monzón Hypoxia and Non-alcoholic Fatty Liver Disease Frontiers in Medicine obstructive sleep apnea NAFLD hypoxia hypoxia-inducible factors (HIFs) hepatosteatosis |
| title | Hypoxia and Non-alcoholic Fatty Liver Disease |
| title_full | Hypoxia and Non-alcoholic Fatty Liver Disease |
| title_fullStr | Hypoxia and Non-alcoholic Fatty Liver Disease |
| title_full_unstemmed | Hypoxia and Non-alcoholic Fatty Liver Disease |
| title_short | Hypoxia and Non-alcoholic Fatty Liver Disease |
| title_sort | hypoxia and non alcoholic fatty liver disease |
| topic | obstructive sleep apnea NAFLD hypoxia hypoxia-inducible factors (HIFs) hepatosteatosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.578001/full |
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