A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss

A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss

IntroductionIt is documented that a series of autoantibodies can be detected with increased frequency in women with recurrent pregnancy loss (RPL) and they may impact the pregnancy prognosis negatively. It is unknown whether the autoantibodies per se or the basic immune disturbances underlying autoa...

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Bibliographic Details
Main Authors: Caroline Nørgaard-Pedersen, Rudi Steffensen, Ulrik Schiøler Kesmodel, Ole Bjarne Christiansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
HLA class II
mannose-binding lectin
autoantibodies
antiphospholipid antibodies
recurrent pregnancy loss
habitual abortion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1069974/full

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