Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development
Summary: The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert−/−) causes extremely poor ability in spatial memory formation. Knockdown of TERT in the dentate gyrus of adult hippocampus impairs spatial memory...
Main Authors: | Qi-Gang Zhou, Meng-Ying Liu, Han-Woong Lee, Fuyuki Ishikawa, Sushil Devkota, Xin-Ru Shen, Xin Jin, Hai-Yin Wu, Zhigang Liu, Xiao Liu, Xun Jin, Hai-Hui Zhou, Eun Jeoung Ro, Jing Zhang, Yu Zhang, Yu-Hui Lin, Hoonkyo Suh, Dong-Ya Zhu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-08-01
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Series: | Stem Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213671117302771 |
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